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15 p, 2.1 MB |
Sex-specific metabolic pathways were associated with alzheimer's disease (Ad) endophenotypes in the european medical information framework for ad multimodal biomarker discovery cohort
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Xu, J. (King's College London) ;
Green, R. (King's College London) ;
Kim, M. (Steno Diabetes Center) ;
Lord, J. (King's College London) ;
Ebshiana, A. (King's College London) ;
Westwood, S. (Department of Psychiatry. University of Oxford) ;
Baird, Alison L (Department of Psychiatry. University of Oxford) ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford) ;
Shi, L. (Department of Psychiatry. University of Oxford) ;
Hye, Abdul (King's College London) ;
Snowden, S. G. (King's College London) ;
Bos, Isabelle (Amsterdam UMC. University Medical Center) ;
Vos, S. J. B. (Maastricht University) ;
Vandenberghe, R. (Alzheimer Center. VU University Medical Center) ;
Teunissen, C. E. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ;
Kate, M. T. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ;
Scheltens, P. (Alzheimer Center. VU University Medical Center) ;
Gabel, Silvy (University Hospitals Leuven (Bèlgica)) ;
Meersmans, K. (University Hospitals Leuven (Bèlgica)) ;
Blin, Olivier (Clinical Pharmacology & Pharmacovigilance Department. Aix-Marseille University-CNRS) ;
Richardson, J. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
De Roeck, Ellen E (University of Antwerp. Institute Born-Bunge) ;
Engelborghs, Sebastiaan (RUniversity of Antwerp. Institute Born-Bunge) ;
Sleegers, Kristel (Complex Genetics of Alzheimer's Disease Group. VIB Center for Molecular Neurology. VIB) ;
Bordet, Régis (Université de Lille. Department of Medical Pharmacology) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kettunen, Petronella (University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, F. R. J. (Maastricht University. Alzheimer Centrum Limburg) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundación CITA-Alzhéimer Fundazioa) ;
Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet) ;
Freund-Levi, Yvonne (King's College London) ;
Frölich, L. (University of Heidelberg. Department of Geriatric Psychiatry) ;
Dobricic, Valerija (University of Lübeck. Institutes of Neurogenetics and Cardiogenetics) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Wallin, Anders (University of Gothenburg. Sahlgrenska Academy) ;
Popp, J. (University Hospital of Psychiatry Zürich) ;
Martinez-Lage, P. (Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Oslo. Department of Psychology) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, J. (Reference Center for Biological Markers of Dementia (BIODEM). Institute Born-Bunge. University of Antwerp) ;
Jelle Visser, P. (Maastricht University. Alzheimer Centrum Limburg) ;
Lovestone, Simon (Janssen-Cilag UK Ltd.) ;
Proitsi, P. (King's College London) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Universitat Autònoma de Barcelona
Background: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. [...]
2021 -  10.3390/biomedicines9111610
Biomedicines, Vol. 9 Núm. 11 (november 2021) , p. 1610
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41 p, 1.2 MB |
Therapeutic potential of emerging NAD+-increasing strategies for cardiovascular diseases
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Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau) ;
Camacho, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ;
Diarte-Añazco, E. M. G. (Institut d'Investigació Biomèdica Sant Pau) ;
Canyelles, Marina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Méndez Lara, Karen Alejandra (Institut d'Investigació Biomèdica Sant Pau) ;
Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Julve i Gil, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. [...]
2021 - 10.3390/antiox10121939
Antioxidants, Vol. 10 Núm. 12 (december 2021) , p. 1939
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14 p, 1.1 MB |
Neuroendocrine and immune responses undertake different fates following tryptophan or methionine dietary treatment : tales from a teleost model
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Azeredo, Rita (Centro Interdisciplinar de Investigação Marinha e Ambiental) ;
Machado, Marina (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Afonso, António (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ;
Fierro Castro, Maria Camino (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Reyes-López, Felipe E. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gesto, Manuel (Universidade de Vigo. Departamento de Bioloxía Funcional e Ciencias da Saúde) ;
Conde-Sieira, Marta (Universidade de Vigo. Departamento de Bioloxía Funcional e Ciencias da Saúde) ;
Míguez, Jesús Manuel (Universidade de Vigo. Departamento de Bioloxía Funcional e Ciencias da Saúde) ;
Soengas, José L. (Universidade de Vigo. Departamento de Bioloxía Funcional e Ciencias da Saúde) ;
Kreuz, Eva (Leibniz-Institute of Freshwater Ecology and Inland Fisheries) ;
Wuertz, Sven (Leibniz-Institute of Freshwater Ecology and Inland Fisheries) ;
Peres, Helena (Centro Interdisciplinar de Investigação Marinha e Ambiental) ;
Oliva-Teles, Aires (Departamento de Biologia, Faculdade de Ciências da Universidade do Porto (FCUP)) ;
Costas, Benjamín (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal))
Methionine and tryptophan appear to be fundamental in specific cellular pathways involved in the immune response mechanisms, including stimulation of T-regulatory cells by tryptophan metabolites or pro-inflammatory effects upon methionine supplementation. [...]
2017 - 10.3389/fimmu.2017.01226
Frontiers in immunology, Vol. 8 (Sep. 2017) , art. 1226
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9 p, 833.3 KB |
A Biomarker to differentiate between primary and cocaine-induced major depression in cocaine use disorder : the role of platelet IRAS/Nischarin (I-Imidazoline receptor)
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Keller, Benjamin (Universitat de les Illes Balears) ;
Mestre-Pinto, Joan-Ignasi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Álvaro-Bartolomé, María (Universitat de les Illes Balears) ;
Martinez-Sanvisens, Diana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Fuster, M. Julia (Universitat de les Illes Balears) ;
García-Sevilla, Jesús A. (Universitat de les Illes Balears) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
The association of cocaine use disorder (CUD) and comorbid major depressive disorder (MDD; CUD/MDD) is characterized by high prevalence and poor treatment outcomes. CUD/MDD may be primary (primary MDD) or cocaine-induced (CUD-induced MDD). [...]
2017 - 10.3389/fpsyt.2017.00258
Frontiers in psychiatry, Vol. 8 (december 2017) , art. 258
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14 p, 1.4 MB |
The Tryptophan System in Cocaine-Induced Depression
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Fonseca, Francina 1972- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Mestre-Pintó, Joan-Ignasi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gomez-Gomez, A (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martinez-Sanvisens, Diana (Hospital del Mar (Barcelona, Catalunya)) ;
Rodríguez-Minguela, Rocío (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Valverde, Olga (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pozo, Óscar J. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Major depression disorder (MDD) is the most prevalent psychiatric comorbid condition in cocaine use disorder (CUD). The comorbid MDD might be primary-MDD (CUD-primary-MDD) or cocaine-induced MDD (CUD-induced-MDD), and their accurate diagnoses and treatment is a challenge for improving prognoses. [...]
2020 - 10.3390/jcm9124103
Journal of clinical medicine, Vol. 9 (december 2020)
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15 p, 1.8 MB |
C-mannosylation supports folding and enhances stability of thrombospondin repeats
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Shcherbakova, Aleksandra (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ;
Preller, Matthias (Medizinische Hochschule Hannover. Institut für Biophysikalische Chemie) ;
Taft, Manuel H. (Medizinische Hochschule Hannover. Institut für Biophysikalische Chemie) ;
Pujols Pujol, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Tiemann, Birgit (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ;
Buettner, Falk F. R. (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ;
Bakker, Hans (Medizinische Hochschule Hannover. Institut für Klinische Biochemie)
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs) of netrin receptor UNC-5. [...]
2019 - 10.7554/eLife.52978
eLife, Vol. 8 (Dec. 2019) , art. e52978
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