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13 p, 896.2 KB |
Secreted Protein Acidic and Rich in Cysteine (SPARC) Polymorphisms in Response to Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer Patients
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Arqueros, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Salazar, Juliana (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Andrés Nieto, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Tibau Martorell, Ariadna (Institut d'Investigació Biomèdica Sant Pau) ;
Bell, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Artigas-Baleri, Alícia (Institut d'Investigació Biomèdica Sant Pau) ;
Lasa, Adriana (Institut d'Investigació Biomèdica Sant Pau) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Lerma Puertas, Enrique (Institut d'Investigació Biomèdica Sant Pau) ;
Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Secreted protein acidic and rich in cysteine (SPARC) expression has been proposed as a prognostic and predictive biomarker for some cancer types, but knowledge about the predictive value of SPARC polymorphisms in the context of neoadjuvant therapy for breast cancer (BC) is lacking. [...]
2023 -  10.3390/biomedicines11123231
Biomedicines, Vol. 11 (december 2023)
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2.
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10 p, 1.7 MB |
HLA-DR Expression on Monocytes and Sepsis Index Are Useful in Predicting Sepsis
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Quirant-Sánchez, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Plans Galván, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lucas, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Argudo, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Arméstar, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
2023 - 10.3390/biomedicines11071836
Biomedicines, Vol. 11, Num. 7, 2023. art. 1836
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4.
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12 p, 1.4 MB |
Association of serum and fecal microRNA profiles in cats with gastrointestinal cancer and chronic inflammatory enteropathy
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Brogaard, Louise (Technical University of Denmark) ;
Lyngby, Janne G. (University of Copenhagen) ;
Kristensen, Annemarie T. (University of Copenhagen) ;
Fredholm, Merete (University of Copenhagen) ;
Bjørnvad, Charlotte R. (University of Copenhagen) ;
Salavati Schmitz, Silke (University of Edinburgh. Royal School of Veterinary Studies) ;
Skancke, Ellen (Norwegian University of the Life Sciences) ;
Morris, Joanna S. (University of Glasgow. School of Veterinary Medicine) ;
Dupont, Nana (University of Copenhagen) ;
Argyle, David (University of Edinburgh. Royal School of Veterinary Studies) ;
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Spohr, Anette (Evidensia Faxe Animal Hospital) ;
Graarup-Hansen, Kasper (Evidensia Karlslunde Animal Hospital) ;
Nielsen, Lise N. (University of Copenhagen) ;
Cirera, Susanna (University of Copenhagen)
Differentiation of gastrointestinal cancer (GIC) from chronic inflammatory enteropathies (CIE) in cats can be challenging and often requires extensive diagnostic testing. MicroRNAs (miRNAs) have promise as non-invasive biomarkers in serum and feces for diagnosis of GIC. [...]
2023 - 10.1111/jvim.16813
Journal of Veterinary Internal Medicine, Vol. 37 (july 2023) , p. 1738-1749
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5.
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12 p, 1.2 MB |
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease
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Startin, Carla M. (LonDownS Consortium (London Down Syndrome Consortium)) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Hamburg, Sarah (LonDownS Consortium (London Down Syndrome Consortium)) ;
Hithersay, Rosalyn (LonDownS Consortium (London Down Syndrome Consortium)) ;
Wiseman, Frances K. (University College London) ;
Mok, Kin Y. (Hong Kong University of Science and Technology) ;
Hardy, John (University College London) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Lovestone, Simon (University of Oxford) ;
Parnetti, Lucilla (University of Perugia) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Hye, Abdul (Maudsley NHS Foundation) ;
Fisher, Elisabeth ;
Nizetic, Dean ;
Tybulewicz, Victor ;
Karmiloff-Smith, Anette ;
Al-Janabi, Tamara ;
Zhang, David ;
Strydom, André (LonDownS Consortium (London Down Syndrome Consortium)) ;
Universitat Autònoma de Barcelona
Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding relevant molecular differences between those with DS, those with sporadic AD (sAD) without DS, and controls will aid in understanding AD development in DS. [...]
2019 - 10.1186/s13195-019-0477-0
Alzheimer's research & therapy, Vol. 11 Núm. 1 (21 2019) , p. 26
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9 p, 1012.4 KB |
Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity : A cross-sectional analysis from the AB255 Study
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Pérez-Grijalba, Virginia (Araclon Biotech S.L.) ;
Arbizu, Javier (Clínica Universidad de Navarra) ;
Romero, Judith (Araclon Biotech S.L.) ;
Prieto, Elena (Clínica Universidad de Navarra) ;
Pesini, Pedro (Araclon Biotech S.L.) ;
Sarasa, Leticia (Araclon Biotech S.L.) ;
Guillen, Fernando (Clínica Universidad de Navarra) ;
Monleón, Inmaculada (Araclon Biotech S.L.) ;
San-José, Itziar (Araclon Biotech S.L.) ;
Martínez-Lage, Pablo (Fundación CITA-Alzheimer) ;
Munuera, Josep (Institut de Recerca Sant Joan de Déu) ;
Hernández, Isabel (Instituto de Salud Carlos III) ;
Buendía, Mar (Universitat Internacional de Catalunya) ;
Sotolongo-Grau, Oscar (Universitat Internacional de Catalunya) ;
Alegret, Montserrat (Instituto de Salud Carlos III) ;
Ruiz, Agustín (Instituto de Salud Carlos III) ;
Tárraga, Lluís (Instituto de Salud Carlos III) ;
Boada, Mercè (Instituto de Salud Carlos III) ;
Sarasa, Manuel (Araclon Biotech S.L.) ;
Goñi Imízcoz, Miguel (Hospital Divino Vallés (Burgos)) ;
Pujadas, Francesc ;
Villarejo, Alberto ;
Frank, Ana ;
Peña-Casanova, Jordi ;
Fernández, Manuel ;
Piñol, Gerard ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Gil, Pedro ;
Pascual, Luis F. ;
Aguilar Barberà, Miquel ;
Frisoni, Giovanni B. ;
Matias-Guiu, Jorge ;
Andreasen, Niels ;
Antúnez, Carmen ;
Universitat Autònoma de Barcelona
To facilitate population screening and clinical trials of disease-modifying therapies for Alzheimer's disease, supportive biomarker information is necessary. This study was aimed to investigate the association of plasma amyloid-beta (Aβ) levels with the presence of pathological accumulation of Aβ in the brain measured by amyloid-PET. [...]
2019 - 10.1186/s13195-019-0549-1
Alzheimer's research & therapy, Vol. 11 Núm. 1 (january 2019) , p. 96
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10 p, 701.1 KB |
Circulating non-coding RNAs in biomarker-guided cardiovascular therapy : A novel tool for personalized medicine?
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Gonzalo Calvo, David de (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vea, Ángela (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bär, C. (Hannover Medical School) ;
Fiedler, J. (Hannover Medical School) ;
Couch, L.S. (Imperial College London) ;
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Llorente-Cortes, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Thum, T. (Hannover Medical School) ;
Universitat Autònoma de Barcelona
Current clinical guidelines emphasize the unmet need for technological innovations to guide physician decision-making and to transit from conventional care to personalized cardiovascular medicine. Biomarker-guided cardiovascular therapy represents an interesting approach to inform tailored treatment selection and monitor ongoing efficacy. [...]
2019 - 10.1093/eurheartj/ehy234
European heart journal, Vol. 40 Núm. 20 (january 2019) , p. 1643-1650
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22 p, 1.6 MB |
Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
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Weber, Minéia (Universitat de Barcelona) ;
Mera, Paula (Instituto de Salud Carlos III) ;
Casas, Josefina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Salvador, Javier (Clínica Universidad de Navarra) ;
Rodríguez, Amaia (Clínica Universidad de Navarra) ;
Alonso, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sebastián, David (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Soler-Vázquez, MCarmen (Universitat de Barcelona) ;
Montironi, Carla (Hospital Clínic i Provincial de Barcelona) ;
Recalde, Sandra (Universitat de Barcelona) ;
Fucho, Raquel (Universitat de Barcelona) ;
Calderon-Dominguez, María (Universitat de Barcelona) ;
Mir, Joan Francesc (Universitat de Barcelona) ;
Bartrons, Ramon (Universitat de Barcelona) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Infantes, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Zorzano Olarte, Antonio (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Llorente-Cortes, Vicenta (Institut d'Investigació Biomèdica Sant Pau) ;
Casals, Nuria (Universitat Internacional de Catalunya) ;
Valentí, Victor (Clínica Universidad de Navarra) ;
Frühbeck, Gema (Clínica Universidad de Navarra) ;
Herrero, Laura (Instituto de Salud Carlos III) ;
Serra, Dolors (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high-fat diet (HFD)-induced obesity and NAFLD in mice by enhancing liver fatty acid oxidation (FAO). [...]
2020 - 10.1096/fj.202000678R
FASEB Journal, Vol. 34 Núm. 9 (january 2020) , p. 11816-11837
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9.
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7 p, 468.8 KB |
ABCB1 Genetic Variants as Predictors of Irinotecan-Induced Severe Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients
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Riera, Pau (Institut d'Investigació Biomèdica Sant Pau) ;
Artigas-Baleri, Alícia (Institut d'Investigació Biomèdica Sant Pau) ;
Salazar, Juliana (Institut d'Investigació Biomèdica Sant Pau) ;
Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Virgili Manrique, Anna Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Arranz, María Jesús (Fundació Docència i Investigació Mútua Terrassa) ;
Páez, David (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Irinotecan is widely used in the treatment of metastatic colorectal cancer (mCRC) despite its severe toxicities. Toxicity is often associated with the UGT1A1*28/*28 genotype. An explanation for idiopathic toxicity beyond the UGT1A1 biomarker, however, remains a major concern for clinicians. [...]
2020 - 10.3389/fphar.2020.00973
Frontiers in Pharmacology, Vol. 11 (30 2020) , p. 973
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8 p, 3.0 MB |
Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT - A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party
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Penack, Olaf (Charité - Universitätsmedizin Berlin) ;
Peczynski, Christophe (EBMT Statistical Unit) ;
van der Werf, Steffie (EBMT Data Office) ;
Finke, Jürgen (University of Freiburg) ;
Ganser, Arnold (Hannover Medical School) ;
Schoemans, Helene (University Hospitals Leuven (Bèlgica)) ;
Pavlu, Jiri (Imperial College London) ;
Niittyvuopio, Riitta (HUCH Comprehensive Cancer Center) ;
Schroyens, W.ilfried (University Hospital Antwerp (Bèlgica)) ;
Kaynar, Leylagül (Erciyes University) ;
Blau, Igor W. (Department of Hematology. Oncology. and Tumor Immunology) ;
van der Velden, Walter J.F.M. (Radboud University) ;
Malouf Sierra, Jorge 1971- (Institut d'Investigació Biomèdica Sant Pau) ;
Cortelezzi, Agostini (University of Milan) ;
Wulf, Gerald (Universitätsklinikum Göttingen) ;
Turlure, Pascal (CHRU Limoges) ;
Rovira Argelagués, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Ozkurt, Zubeydenur (Gazi University) ;
Pascual-Cascon, Maria J. (Hospital Regional Universitario de Málaga) ;
Moreira, Maria C. (Instituto National do Cancer) ;
Clausen, Johannes (Ordensklinikum Linz Elisabethinen) ;
Greinix, Hildegard (Medical University of Graz) ;
Duarte, Rafael F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Basak, Grzegorz (Medical University of Warsaw) ;
Universitat Autònoma de Barcelona
Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high serum ferritin levels with increased mortality after alloSCT has been suggested by several retrospective analyses as well as by two smaller prospective studies. [...]
2020 - 10.3389/fimmu.2020.00586
Frontiers in immunology, Vol. 11 (15 2020) , p. 586
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