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13 p, 1.9 MB |
Genetic characterization of the ALFA study : Uncovering genetic profiles in the Alzheimer's continuum
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Vilor-Tejedor, Natalia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Genius, Patricia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Fernández, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Minguillón, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sadeghi, Iman (Centre de Regulació Genòmica) ;
González-Escalante, Armand (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Crous-Bou, Marta (Hospital Universitari de Bellvitge) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Brugulat-Serrat, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fauria, Karine (Pasqual Maragall Foundation) ;
Molinuevo, José Luis (Pasqual Maragall Foundation) ;
Navarro, Arcadi 1969- (Universitat Pompeu Fabra) ;
Gispert, Juan Domingo (Institut Hospital del Mar d'Investigacions Mèdiques)
INTRODUCTION: In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive interventions. [...]
2023 -  10.1002/alz.13537
Alzheimer's & Dementia, 2023
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11 p, 1001.7 KB |
Genetic predisposition to alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
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Ciampa, Iacopo (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Operto, Grégory (Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable) ;
Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Minguillon, Carolina (Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Universitat de Barcelona) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Guigó, Roderic (Barcelona Institute of Science and Technology (BIST)) ;
Navarro, Arcadi 1969- (Universitat Pompeu Fabra) ;
Gispert, Juan Domingo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Vilor-Tejedor, Natalia (Erasmus University Medical Center Rotterdam) ;
Universitat Autònoma de Barcelona
This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. [...]
2021 - 10.3390/genes12060825
Genes, Vol. 12 Núm. 6 (june 2021) , p. 825
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10 p, 1005.4 KB |
Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease : a cross-sectional analysis from the ALFA (Alzheimer and Families) project
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Brugulat-Serrat, Anna (Barcelonaβeta Brain Research Center (BBRC)) ;
Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Bargalló, Núria (Centre Mèdic Diagnòstic Alomar) ;
Conesa, Gerardo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Minguillón, Carolina (Barcelonaβeta Brain Research Center (BBRC)) ;
Fauria, Karine (Barcelonaβeta Brain Research Center (BBRC)) ;
Gramunt, Nina (Barcelonaβeta Brain Research Center (BBRC)) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Gispert, Juan Domingo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). Cross-sectional observational study. [...]
2017 - 10.1136/bmjopen-2016-013215
BMJ open, Vol. 7 (march 2017)
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15 p, 2.4 MB |
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
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Vilor-Tejedor, N. (Universitat Pompeu Fabra) ;
Operto, Gregory (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Evans, T. E. (Erasmus MC University Medical Center Rotterdam. Department of Clinical Genetics) ;
Falcon, Carles (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Crous-Bou, Marta (Institut Català d'Oncologia) ;
Minguillón, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cacciaglia, Raffaele (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Milà-Alomà, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Garrido-Martín, Diego (Centre de Regulació Genòmica) ;
Moran, S (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Adams, Hieab (Erasmus MC University Medical Center Rotterdam. Department of Radiology) ;
Molinuevo, José Luis (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guigó, R. (Universitat Pompeu Fabra) ;
Gispert, Juan Domingo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association of Val66Met with whole hippocampal volume included patients of a variety of disorders. [...]
2020 - 10.1007/s00429-020-02125-3
Brain Structure and Function, Vol. 225 Núm. 8 (january 2020) , p. 2331-2345
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10 p, 838.9 KB |
The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
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Gispert, Juan Domingo (Universitat Pompeu Fabra) ;
Monté, Gemma C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany) ;
Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Tucholka, Alan (Barcelonaβeta Brain Research Center (BBRC)) ;
Rojas, Santiago (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Llado Plarrumani, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Haass, Christian (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Among other metabolic functions, the apolipoprotein E (APOE) plays a crucial role in neuroinflammation. We aimed at assessing whether APOE ε4 modulates levels of glial cerebrospinal fluid (CSF) biomarkers and their structural cerebral correlates along the continuum of Alzheimer's disease (AD). [...]
2016 - 10.1016/j.dadm.2016.12.002
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 6 (december 2016) , p. 50-59
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11 p, 519.1 KB |
2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
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Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ;
Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ;
Araque Caballero, Miguel Ángel (Ludwig-Maximilians-University Munich) ;
Brendel, Matthias (Ludwig-Maximilians-University Munich) ;
Rominger, Axel (Ludwig-Maximilians-University Munich) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Gispert, Juan Domingo (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Antonell, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Brosseron, Frederic (German Center for Neurodegenerative Diseases (DZNE)) ;
Traschütz, Andreas (Universitätsklinikum Bonn) ;
Heneka, Michael T. (Universitätsklinikum Bonn) ;
Struyfs, Hanne (University Hospital Antwerp (Bèlgica)) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Van Broeckhoven, Christine (University of Antwerp. Institute Born-Bunge) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Nellgård, Bengt (Gothenburg University. Sahlgrenska Academy. Institute of Clinical Sciences) ;
Blennow, Kaj (The Sahlgrenska Academy at the University of Gothenburg. Institute of Neuroscience and Physiology) ;
Crispin, Alexander (Institute of Medical Informatics, Biometry, and Epidemiology) ;
Ewers, Michael (Ludwig-Maximilians-University Munich) ;
Haass, Christian (BioMedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich) ;
Universitat Autònoma de Barcelona
2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations of 2 are associated with increased risk of Alzheimer's disease (). 2 is a type-1 protein with an ectodomain that is proteolytically cleaved and released into the extracellular space as a soluble variant (2), which can be measured in the cerebrospinal fluid (). [...]
2016 - 10.15252/emmm.201506123
EMBO Molecular Medicine, Vol. 8 (march 2016) , p. 466-476
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