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16 p, 1.0 MB |
Synthesis and evaluation of aromatic BDSF bioisosteres on biofilm formation and colistin sensitivity in pathogenic bacteria
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Horgan, Conor (University College Cork) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
O'Driscoll, Michelle (University College Cork) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy (University College Cork)
The diffusible signal factor family (DSF) of molecules play an important role in regulating intercellular communication, or quorum sensing, in several disease-causing bacteria. These messenger molecules, which are comprised of cis-unsaturated fatty acids, are involved in the regulation of biofilm formation, antibiotic tolerance, virulence and the control of bacterial resistance. [...]
2023 -  10.1016/j.ejmech.2023.115819
European Journal of Medicinal Chemistry, Vol. 261 (December 2023) , art. 115819
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12 p, 4.4 MB |
A high-throughput microtiter plate screening assay to quantify and differentiate species in dual-species biofilms
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Campo Pérez, Víctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alcàcer-Almansa, Júlia (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Torrents, Eduard (Institut de Bioenginyeria de Catalunya)
Pathogenic bacteria form biofilms during infection, and polymicrobial biofilms are the most frequent manifestation. Biofilm attachment, maturation, and/or antibiotic sensitivity are mainly evaluated with microtiter plate assays, in which bacteria are stained to enable the quantification of the biomass by optical absorbance or fluorescence emission. [...]
2023 - 10.3390/microorganisms11092244
Microorganisms, Vol. 11, issue 9 (Sep. 2023) , art. 2244
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16 p, 3.2 MB |
In Vitro Antibacterial Activity of Silver Nanoparticles Conjugated with Amikacin and Combined with Hyperthermia against Drug-Resistant and Biofilm-Producing Strains
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Palau Gauthier, Marta (Hospital Universitari Vall d'Hebron) ;
Muñoz, Estela (Hospital Universitari Vall d'Hebron) ;
Gustà, Muriel F. (Institut Català de Nanociència i Nanotecnologia) ;
Larrosa, María Nieves (Hospital Universitari Vall d'Hebron) ;
Gomis, Xavier (Hospital Universitari Vall d'Hebron) ;
Gilabert, Joan (Tractivus SL) ;
Almirante Gragera, Benito (Hospital Universitari Vall d'Hebron) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Texidó, Robert (Institució Catalana de Recerca i Estudis Avançats) ;
Gavaldà, Joan (Hospital Universitari Vall d'Hebron)
In view of the current increase and spread of antimicrobial resistance (AMR), there is an urgent need to find new strategies to combat it. This study had two aims. First, we synthesized highly monodispersed silver nanoparticles (AgNPs) of approximately 17 nm, and we functionalized them with mercaptopoly(ethylene glycol) carboxylic acid (mPEG-COOH) and amikacin (AK). [...]
2023 - 10.1128/spectrum.00280-23
Microbiology Spectrum, Vol. 11, Issue 3 (June 2023) , art. 00280-23
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16 p, 7.0 MB |
Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lyons, Thérèse (University College Cork. School of Pharmacy) ;
Mamat, Uwe (Leibniz Lung Center. Cellular Microbiology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Elshafee, Osama (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Brunke, Sascha (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Gahan, Cormac G.M. (University College Cork. APC Microbiome Ireland) ;
O'Driscoll, Michelle (University College Cork. Analytical and Biological Chemistry Research Facility) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy P. (University College Cork. Analytical and Biological Chemistry Research Facility)
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. [...]
2022 - 10.1016/j.ejmech.2022.114678
European Journal of Medicinal Chemistry, Vol. 242 (November 2022) , art. 114678
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