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11.
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136 p, 5.5 MB |
The unique role of Angiogenin in neuroprotection and neurorepair after cerebral ischemia
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Lei, Ting ;
Rosell Novel, Anna, dir. ;
Montaner Villalonga, Joan, dir.
L'ictus és una de les principals causes de mort i discapacitat a tot el món amb un gran impacte socioeconòmic i costos sanitaris. Dades recents mostren que hi ha més de 13 milions de nous ictus anualment, una de cada quatre persones majors de 25 anys tindrà un ictus, 80 milions de persones viuen amb les conseqüències d'un ictus i més de cinc milions de persones moren d'aquesta malaltia anualment. [...]
El ictus es una de las principales causas de muerte y discapacidad en todo el mundo con un gran impacto socioeconómico y costes sanitarios. Datos recientes muestran que hay más de 13 millones de nuevos ictus anualmente, una de cada cuatro personas mayores de 25 años tendrá un ictus, 80 millones de personas viven con las secuelas de un ictus y más de cinco millones de personas mueren de esta enfermedad anualmente. [...]
Stroke is a leading cause of death and disability worldwide with major socioeconomic impact and healthcare costs. In this regard recent data shows that there are over 13 million new strokes annually, one in four people over age 25 will have a stroke in their lifetime, 80 million people are currently living with the consequences of a stroke and more than five million people die from stroke annually. [...]
2021
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12.
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10 p, 1.5 MB |
Angiogenin in the Neurogenic Subventricular Zone After Stroke
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Gabriel Salazar, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lei, Ting (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grayston, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Medina-Gutiérrez, Esperanza (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Ischemic stroke is a leading cause of death and disability worldwide with effective acute thrombolytic treatments. However, brain repair mechanisms related to spontaneous or rehabilitation-induced recovery are still under investigation, and little is known about the molecules involved. [...]
2021 -  10.3389/fneur.2021.662235
Frontiers in neurology, Vol. 12 (june 2021)
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13.
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14 p, 1.2 MB |
Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders
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Seras-Franzoso, Joaquin (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Díaz Riascos, Zamira Vanessa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona) ;
González, Patricia (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
García Aranda, Natalia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mandaña, Mònica (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Riera, Roger (Institut de Bioenginyeria de Catalunya) ;
Boullosa, Ana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mancilla, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Grayston, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Moltó-Abad, Marc (Hospital Universitari Vall d'Hebron) ;
Garcia-Fruitos, Elena (Universitat Autònoma de Barcelona) ;
Mendoza, Rosa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pintos-Morell, Guillem (Hospital Universitari Vall d'Hebron) ;
Albertazzi, Lorenzo (Institut de Bioenginyeria de Catalunya) ;
Rosell Novel, Anna (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Casas, Josefina (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Schwartz, Simó (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Abasolo, Ibane (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
In the present study the use of extracellular vesicles (EVs) as vehicles for therapeutic enzymes in lysosomal storage disorders was explored. EVs were isolated from mammalian cells overexpressing alpha-galactosidase A (GLA) or N-sulfoglucosamine sulfohydrolase (SGSH) enzymes, defective in Fabry and Sanfilippo A diseases, respectively. [...]
2021 - 10.1002/jev2.12058
Journal of extracellular vesicles, Vol. 10 (march 2021)
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14.
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10 p, 3.9 MB |
Factors Secreted by Endothelial Progenitor Cells Enhance Neurorepair Responses after Cerebral Ischemia in Mice
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Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morancho, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro Sobrino, Míriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lope-Piedrafita, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barceló, Verónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borràs i Serres, Francesc Enric (Hospital Universitari Vall d'Hebron) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García Bonilla, Lídia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cell therapy with endothelial progenitor cells (EPCs) has emerged as a promising strategy to regenerate the brain after stroke. Here, we aimed to investigate if treatment with EPCs or their secreted factors could potentiate angiogenesis and neurogenesis after permanent focal cerebral ischemia in a mouse model of ischemic stroke. [...]
2013 - 10.1371/journal.pone.0073244
PloS one, Vol. 8 (september 2013)
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15.
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16.
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5.3 MB |
Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia
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Gabriel Salazar, Marina (Hospital Universitari Vall d'Hebron) ;
Morancho, Anna (Hospital Universitari Vall d'Hebron) ;
Rodriguez, Susana (Hospital Universitari Vall d'Hebron) ;
Buxo Masip, Xavier (Hospital Universitari Vall d'Hebron) ;
García-Rodríguez, Nicolás (Hospital Universitari Vall d'Hebron) ;
Colell, Guillem (Hospital Universitari Vall d'Hebron) ;
Fernandez, Albert (Hospital Universitari Vall d'Hebron) ;
Giralt, Dolors (Hospital Universitari Vall d'Hebron) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: Rehabilitation therapy is the only available treatment for stroke survivors presenting neurological deficits; however, the underlying molecules and mechanisms associated with functional/motor improvement during rehabilitation are poorly understood. [...]
2018 - 10.3389/fneur.2018.00508
Frontiers in neurology, Vol. 9 (june 2018)
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17.
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14 p, 2.3 MB |
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology
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Simats Oriol, Alba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giralt, Dolors (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gill, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The limited accessibility to the brain has turned the cerebrospinal fluid (CSF) into a valuable source that may contribute to the complete understanding of the stroke pathophysiology. Here we have described the CSF proteome in the hyper-acute phase of cerebral ischemia by performing an aptamer-based proteomic assay (SOMAscan) in CSF samples collected before and 30 min after male Wistar rats had undergone a 90 min Middle Cerebral Artery Occlusion (MCAO) or sham-surgery. [...]
2018 - 10.1038/s41598-018-26237-3
Scientific reports, Vol. 8 (may 2018)
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18.
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19.
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21 p, 1020.6 KB |
Potential of Extracellular Vesicle-Associated TSG-6 from Adipose Mesenchymal Stromal Cells in Traumatic Brain Injury
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Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clos Sansalvador, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Multipotent mesenchymal stromal cells (MSC) represent a promising strategy for a variety of medical applications. Although only a limited number of MSC engraft and survive after in vivo cellular infusion, MSC have shown beneficial effects on immunomodulation and tissue repair. [...]
2020 - 10.3390/ijms21186761
International journal of molecular sciences, Vol. 21 (september 2020)
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20.
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16 p, 3.7 MB |
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
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Pitrez, Patricia R. (University of Coimbra) ;
Estronca, Luís (University of Coimbra) ;
Monteiro, Luís Miguel (University of Coimbra) ;
Colell, Guillem (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vazão, Helena (University of Coimbra) ;
Santinha, Deolinda (University of Coimbra) ;
Harhouri, Karim (Aix Marseille Univ) ;
Thornton, Daniel (University of Liverpool) ;
Navarro, Claire (Progelife (França)) ;
Egesipe, Anne-Laure (Institute for Stem Cell Therapy and Exploration of Monogenic Diseases) ;
Carvalho, Tânia (Universidade de Lisboa) ;
Dos Santos, Rodrigo L. (Cambridge Science Park) ;
Lévy, Nicolas (La Timone Children's Hospital) ;
Smith, James C. (Francis Crick Institute) ;
de Magalhaes, Joao Pedro (University of Liverpool. Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease) ;
Ori, Alessandro (Leibniz Institute on Aging) ;
Bernardo, Andreia (Francis Crick Institute) ;
De Sandre-Giovannoli, Annachiara (CRB Assistance Publique des Hôpitaux de Marseille) ;
Nissan, Xavier (Institute for Stem Cell Therapy and Exploration of Monogenic Diseases (França)) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferreira, Lino (University of Coimbra) ;
Universitat Autònoma de Barcelona
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. [...]
2020 - 10.1038/s41467-020-17901-2
Nature communications, Vol. 11 (august 2020)
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