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21.
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26 p, 9.8 MB |
Presenilin/γ-secretase-dependent epha3 processing mediates axon elongation through non-muscle myosin IIA
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Javier, Miriam (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Marco, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rocandio, Daniel (Institut de Recerca Biomèdica de Lleida) ;
Pons Vizcarra, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Janes, Peter W. (Tumour Targeting Program. Olivia Newton-John Cancer Research Institute) ;
Lackmann, Martin (Department of Biochemistry and Molecular Biology. Monash University) ;
Egea, Joaquim (Institut de Recerca Biomèdica de Lleida) ;
Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. [...]
2019 -  10.7554/eLife.43646
eLife, Vol. 8 (october 2019) , p. e43646
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22.
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15 p, 1.8 MB |
C-mannosylation supports folding and enhances stability of thrombospondin repeats
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Shcherbakova, Aleksandra (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ;
Preller, Matthias (Medizinische Hochschule Hannover. Institut für Biophysikalische Chemie) ;
Taft, Manuel H. (Medizinische Hochschule Hannover. Institut für Biophysikalische Chemie) ;
Pujols Pujol, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Tiemann, Birgit (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ;
Buettner, Falk F. R. (Medizinische Hochschule Hannover. Institut für Klinische Biochemie) ;
Bakker, Hans (Medizinische Hochschule Hannover. Institut für Klinische Biochemie)
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs) of netrin receptor UNC-5. [...]
2019 - 10.7554/eLife.52978
eLife, Vol. 8 (Dec. 2019) , art. e52978
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23.
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36 p, 10.5 MB |
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism
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Malone, Samuel Andrew (Jean-Pierre Aubert Research Center) ;
Papadakis, Georgios E. (Lausanne University Hospital) ;
Messina, Andrea (Lausanne University Hospital) ;
Mimouni, Nour El Houda (Jean-Pierre Aubert Research Center) ;
Trova, Sara (Jean-Pierre Aubert Research Center) ;
Imbernon, Monica (Jean-Pierre Aubert Research Center) ;
Allet, Cecile (Jean-Pierre Aubert Research Center) ;
Cimino, Irene (Jean-Pierre Aubert Research Center) ;
Acierno, James (Lausanne University Hospital) ;
Cassatella, Daniele (Lausanne University Hospital) ;
Xu, Cheng (Lausanne University Hospital) ;
Quinton, Richard (University of Newcastle-upon-Tyne. Institute of Genetic Medicine) ;
Szinnai, Gabor (University Children's Hospital Basel (Basilea, Suïssa)) ;
Pigny, Pascal (Centre de Biologie Pathologie Génétique. Service Hormonologie Métabolisme Nutrition Oncologie) ;
Alonso-Cotchico, Lur (Universitat Autònoma de Barcelona. Departament de Química) ;
Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Prevot, V. (Jean-Pierre Aubert Research Center) ;
Pitteloud, Nelly (Lausanne University Hospital) ;
Giacobini, Polo (Jean-Pierre Aubert Research Center)
Congenital hypogonadotropic hypogonadism (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing hormone (GnRH) deficiency, which is often associated with anosmia (Kallmann syndrome, KS). [...]
2019 - 10.7554/eLife.47198
eLife, Vol. 8 (2019) , art. e47198
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24.
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19 p, 5.8 MB |
Giant extinct caiman breaks constraint on the axial skeleton of extant crocodylians
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Scheyer, Torsten M. (University of Zurich. Paläontologisches Institut und Museum) ;
Hutchinson, John R. (University of London. Royal Veterinary College (Hatfield, Regne Unit)) ;
Delfino, Massimo (Institut Català de Paleontologia Miquel Crusafont) ;
Strauss, Olivier (University of Zurich. Paläontologisches Institut und Museum) ;
Carrillo-Briceño, Jorge Domingo (University of Zurich. Paläontologisches Institut und Museum) ;
Sánchez, Rodolfo (Museo Paleontológico de Urumaco (Urumaco, Veneçuela)) ;
Sánchez-Villagra, Marcelo R. (University of Zurich. Paläontologisches Institut und Museum)
The number of precaudal vertebrae in all extant crocodylians is remarkably conservative, with nine cervicals, 15 dorsals and two sacrals, a pattern present also in their closest extinct relatives. The consistent vertebral count indicates a tight control of axial patterning by Hox genes during development. [...]
2019 - 10.7554/eLife.49972
eLife, 2019, art. e49972
2 documentos
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25.
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26 p, 4.7 MB |
Defined neuronal populations drive fatal phenotype in a mouse model of leigh syndrome
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Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sanz, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Prada Dacasa, Patricia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Menardy, Fabien (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bard, Angela M. (Seattle Children's Research Institute) ;
Machuca Márquez, Pablo (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Eraso-Pichot, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Mòdol Caballero, Guillem (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Kalume, Frank (Department of Pharmacology. University of Washington) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical in Leigh Syndrome (LS), a common MD presentation, leading to motor and respiratory deficits, seizures and premature death. [...]
2019 - 10.7554/eLife.47163
eLife, Vol. 8 (august 2019) , p. e47163
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26.
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48 p, 6.4 MB |
Oldest skeleton of a fossil flying squirrel casts new light on the phylogeny of the group
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Casanovas i Vilar, Isaac (Institut Català de Paleontologia Miquel Crusafont) ;
Garcia-Porta, Joan (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Fortuny, Josep (Institut Català de Paleontologia Miquel Crusafont) ;
Sanisidro, Oscar (University of Kansas. Biodiversity Institute) ;
Prieto, Jérôme (Ludwig-Maximilians-Universität München. Department für Geo- und Umweltwissenschaften) ;
Querejeta, Marina (Bavarian State Collection of Zoology) ;
Llácer, Sergio (Institut Català de Paleontologia Miquel Crusafont) ;
Robles Gimenez, Josep Maria (Institut Català de Paleontologia Miquel Crusafont) ;
Bernardini, Federico (Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi) ;
Alba, David M.. (Institut Català de Paleontologia Miquel Crusafont)
Flying squirrels are the only group of gliding mammals with a remarkable diversity and wide geographical range. However, their evolutionary story is not well known. Thus far, identification of extinct flying squirrels has been exclusively based on dental features, which, contrary to certain postcranial characters, are not unique to them. [...]
2018 - 10.7554/eLife.39270
eLife, Vol. 7 (October 2018) , art. e39270
2 documentos
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28.
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24 p, 5.3 MB |
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
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Povedano, Juan Manuel ;
Martinez, Paula ;
Serrano, Rosa ;
Tejera, Águeda ;
Gómez-López, Gonzalo ;
Bobadilla, Maria ;
Flores, Juana Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Bosch i Tubert, Fàtima ;
Blasco, María A.
Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. [...]
2018 - 10.7554/eLife.31299
eLife, Vol. 7 (january 2018)
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29.
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20 p, 2.1 MB |
Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator
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Font Inglès, Joan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
López-Cano, Marc (Institut d'Investigació Biomèdica de Bellvitge) ;
Notartomaso, Serena (I.R.C.C.S. Neuromed, Pozzilli, Italy) ;
Scarselli, Pamela (I.R.C.C.S. Neuromed, Pozzilli, Italy) ;
Di Pietro, Paola (I.R.C.C.S. Neuromed, Pozzilli, Italy) ;
Bresolí-Obach, Roger (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ;
Battaglia, Giuseppe (I.R.C.C.S. Neuromed, Pozzilli, Italy) ;
Malhaire, Fanny (Université de Montpellier) ;
Rovira, Xavier (Université de Montpellier) ;
Catena, Juanlo (Institut de Química Avançada de Catalunya) ;
Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pin, Jean-Philippe (Université de Montpellier) ;
Fernández-Dueñas, Víctor (Institut d'Investigació Biomèdica de Bellvitge) ;
Goudet, Cyril (Université de Montpellier) ;
Nonell, Santi (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ;
Nicoletti, Ferdinando (I.R.C.C.S. Neuromed, Pozzilli, Italy) ;
Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ;
Ciruela, Francisco (Institut d'Investigació Biomèdica de Bellvitge)
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i. e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulator raseglurant. [...]
2017 - 10.7554/eLife.23545
eLife, Vol. 6 (april 2017)
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30.
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19 p, 4.3 MB |
Experimental and observational studies find contrasting responses of soil nutrients to climate change
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Yuan, Zhiyou ;
Jiao, Feng ;
Shi, X. R. ;
Sardans i Galobart, Jordi (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Peñuelas, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Manipulative experiments and observations along environmental gradients, the two most common approaches to evaluate the impacts of climate change on nutrient cycling, are generally assumed to produce similar results, but this assumption has rarely been tested. [...]
2017 - 10.7554/eLife.23255
eLife, Vol 6, art e23255 (June 2017)
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