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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 -  10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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11 p, 1.4 MB |
APOE ϵ4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease
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Konijnenberg, Elles (Alzheimer Center Amsterdam) ;
Tijms, Betty M. (Alzheimer Center Amsterdam) ;
Gobom, Johan (University of Gothenburg) ;
Dobricic, Valerija (University of Lübeck) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Popp, Julius (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Frölich, Lutz (University of Heidelberg) ;
Lovestone, Simon (Janssen RandD) ;
Streffer, Johannes (Janssen RandD) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (University of Gothenburg) ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Veerhuis, Robert (Vrije Universiteit Amsterdam) ;
Smit, August B. (Vrije Universiteit Amsterdam) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Visser, Pieter Jelle (Karolinska Instutet) ;
Universitat Autònoma de Barcelona
Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer's disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein E (APOE) ϵ4 genotype plays a major role. [...]
2020 - 10.1186/s13195-020-00628-z
Alzheimer's research & therapy, Vol. 12 Núm. 1 (27 2020) , p. 65
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11 p, 708.4 KB |
DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients
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Moreau, Manon (Université Paris Cité) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Dalzon, Lorraine (Université Paris Cité) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Vilaire, Marie (Institut Médical Jérôme Lejeune) ;
Durand, Sophie (Institut Médical Jérôme Lejeune) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Rebillat, Anne-Sophie (Institut Médical Jérôme Lejeune) ;
Janel, Nathalie (Université Paris Cité) ;
Universitat Autònoma de Barcelona
Down syndrome (DS) is a complex genetic condition due to an additional copy of human chromosome 21, which results in the deregulation of many genes. In addition to the intellectual disability associated with DS, adults with DS also have an ultrahigh risk of developing early onset Alzheimer's disease dementia. [...]
2022 - 10.3390/biomedicines10061380
Biomedicines, Vol. 10 (june 2022)
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15 p, 2.2 MB |
Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
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Lantero-Rodríguez, Juan (University of Gothenburg) ;
Vrillon, Agathe (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ;
Fernández-Lebrero, Aida (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ortiz-Romero, Paula (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Snellman, Anniina (University of Turku) ;
Montoliu-Gaya, Laia (the Sahlgrenska Academy at the University of Gothenburg) ;
Brum, Wagner S. (Universidade Federal do Rio Grande do Sul (UFRGS)) ;
Cognat, Emmanuel (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ;
Dumurgier, Julien (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ;
Puig-Pijoan, Albert (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Navalpotro-Gómez, Irene (Institut Hospital del Mar d'Investigacions Mèdiques) ;
García-Escobar, Greta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Karikari, Thomas K. (University of Pittsburgh) ;
Vanmechelen, Eugeen (ADx NeuroSciences (Ghent, Bèlgica)) ;
Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ;
Zetterberg, Henrik (University of Wisconsin School of Medicine and Public Health) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Paquet, Claire (Groupe Hospitalo Universitaire Assistance Publique Hôpitaux de Paris Nord Hôpital Lariboisière Fernand-Widal) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia))
Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient landscape found in clinical settings. [...]
2023 - 10.1186/s13195-023-01201-0
Alzheimer's research & therapy, Vol. 15 (march 2023)
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27 p, 3.4 MB |
T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells
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Battram, Anthony M (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oliver-Caldés, Aina (Hospital Clínic i Provincial de Barcelona) ;
Suárez Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ;
Lozano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Bosch i Crespo, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez Cibrián, Núria (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Hospital Clínic i Provincial de Barcelona) ;
Moreno, David F. (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ;
Urbano Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández de Larrea, Carlos (Universitat de Barcelona)
Autologous cell immunotherapy using B cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T cells is an effective novel treatment for multiple myeloma (MM). This therapy has only been used for relapsed and refractory patients, at which stage the endogenous T cells used to produce the CAR-T cells are affected by the immunosuppressive nature of advanced MM and/or side effects of previous therapies. [...]
2022 - 10.1016/j.omtm.2022.06.010
Molecular Therapy. Methods & Clinical Development, Vol. 26 (august 2022) , p. 207-223
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23 p, 2.3 MB |
Clinical and magnetic resonance imaging features, and pathological findings of spinal lymphoma in 27 cats
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Lorenzo Fernández, Valentina (Neurología Veterinaria) ;
Ribeiro, João (Faculdade de Medicina Veterinária da Universidade Lusófona de Humanidades e Tecnologias de Lisboa) ;
Bernardini, Marco (Department of Animal Medicine, Production and Health, University of Padua) ;
Mínguez, Juan J. (Scarsdale Vets-Pride Veterinary Centre) ;
Moral Solés, Meritxell (Neurología Veterinaria) ;
Blanco, Carlos (Neurología Veterinaria) ;
Loncarica, Tina (Anicura Ospedale Veterinario I Portoni Rossi) ;
Gamito, Araceli (Hospital Veterinario Guadiamar) ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
This multicentric retrospective study describes the clinical and MRI features and pathological studies of spinal lymphoma in 27 cats. MRI characteristics and their possible correlations with histopathological findings were studied. [...]
2022 - 10.3389/fvets.2022.980414
Frontiers in Veterinary Science, Vol. 9 (october 2022)
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7 p, 835.6 KB |
Blood amyloid and tau biomarkers as predictors of cerebrospinal fluid profiles
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Delaby, Constance (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Hirtz, Christophe (Univ Montpellier, CHU Montpellier, INM INSERM. Laboratoire de Biochimie Protéomique Clinique (LBPC-PPC)) ;
Vialaret, Jérôme (Université de Montpellier) ;
Kindermans, Jana (Université de Montpellier) ;
Morichon, Lisa (Université de Montpellier) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ;
Gabelle, Audrey (Université de Montpellier) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (Hong Kong Center for Neurodegenerative Diseases) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Lehmann, Sylvain (Université de Montpellier) ;
Universitat Autònoma de Barcelona
Blood biomarkers represent a major advance for improving the management, diagnosis, and monitoring of Alzheimer's disease (AD). However, their context of use in relation to routine cerebrospinal fluid (CSF) analysis for the quantification of amyloid peptides and tau proteins remains to be determined. [...]
2022 - 10.1007/s00702-022-02474-9
Journal of Neural Transmission, Vol. 129 (february 2022) , p. 231-237
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12 p, 766.2 KB |
African swine fever virus infection in Classical swine fever subclinically infected wild boars
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Cabezón Ponsoda, Óscar (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Muñoz-González, Sara (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Colom Cadena, Andreu (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Pérez-Simó, Marta (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Rosell, Rosa (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Lavín González, Santiago (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Marco, Ignasi (Universitat Autònoma de Barcelona. Servei d'Ecopatologia de Fauna Salvatge) ;
Fraile, Lorenzo (Universitat de Lleida. Departament de Producció Animal) ;
de la Riva, Paloma Martínez (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya). Departamento de Biotecnología) ;
Rodriguez, Fernando (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Domínguez, Javier (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya). Departamento de Biotecnología) ;
Ganges, Llilianne (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Recently moderate-virulence classical swine fever virus (CSFV) strains have been proven capable of generating postnatal persistent infection (PI), defined by the maintenance of viremia and the inability to generate CSFV-specific immune responses in animals. [...]
2017 - 10.1186/s12917-017-1150-0
BMC veterinary research, Vol. 13 (august 2017)
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5 p, 264.8 KB |
Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease
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Perea, Juan R. (Centro de Biología Molecular Severo Ochoa) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Ávila, Jesús (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Bolós, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. [...]
2018 - 10.3389/fnins.2018.00609
Frontiers in Neuroscience, Vol. 12 (september 2018)
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12 p, 1.7 MB |
Cerebrospinal fluid A beta 1-40 peptides increase in Alzheimer's disease and are highly correlated with phospho-tau in control individuals
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Lehmann, Sylvain (Univ Montpellier) ;
Dumurgier, Julien (Université Paris Diderot) ;
Ayrignac, Xavier (Univ Montpellier) ;
Marelli, Cecilia (Univ Montpellier) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Thouvenot, Eric (Univ Montpellier) ;
Delaby, Constance (Univ Montpellier) ;
Hirtz, Christophe (Univ Montpellier) ;
Vialaret, Jérôme (Univ Montpellier) ;
Ginestet, Nelly (Univ Montpellier) ;
Bouaziz-Amar, Elodie (Université Paris Diderot) ;
Laplanche, Jean-Louis (Université Paris Diderot) ;
Labauge, Pierre (Univ Montpellier) ;
Paquet, Claire (Université Paris Diderot) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Gabelle, Audrey (Univ Montpellier) ;
Universitat Autònoma de Barcelona
Amyloid pathology, which is one of the characteristics of Alzheimer's disease (AD), results from altered metabolism of the beta-amyloid (Aβ) peptide in terms of synthesis, clearance, or aggregation. [...]
2020 - 10.1186/s13195-020-00696-1
Alzheimer's research & therapy, Vol. 12 (october 2020)
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