When Spinal Neuromodulation Meets Sensorimotor Rehabilitation : Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury
Flores, África (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
López-Santos, Diego (Universitat Autònoma de Barcelona. Institut de Neurociències)
García Alias, Guillermo (Institut Germans Trias i Pujol. Institut Guttmann)

Date:	2021
Abstract:	Electrical neuromodulation has strongly hit the foundations of spinal cord injury and repair. Clinical and experimental studies have demonstrated the ability to neuromodulate and engage spinal cord circuits to recover volitional motor functions lost after the injury. Although the science and technology behind electrical neuromodulation has attracted much of the attention, it cannot be obviated that electrical stimulation must be applied concomitantly to sensorimotor rehabilitation, and one would be very difficult to understand without the other, as both need to be finely tuned to efficiently execute movements. The present review explores the difficulties faced by experimental and clinical neuroscientists when attempting to neuromodulate and rehabilitate manual dexterity in spinal cord injured subjects. From a translational point of view, we will describe the major rehabilitation interventions employed in animal research to promote recovery of forelimb motor function. On the other hand, we will outline some of the state-of-the-art findings when applying electrical neuromodulation to the spinal cord in animal models and human patients, highlighting how evidences from lumbar stimulation are paving the path to cervical neuromodulation.
Grants:	Ministerio de Economía, Industria y Competitividad SAF2016-79279-R Fundació la Marató de TV3 201713-30
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Activity-dependent plasticity ; Neuromodulation ; Rehabilitation ; Spinal cord injury ; Upper limb
Published in:	Frontiers in Rehabilitation Sciences, Vol. 2 (December 2021) , art. 755963, ISSN 2673-6861

DOI: 10.3389/fresc.2021.755963
PMID: 36188826

19 p, 4.1 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles