|
1.
|
|
10 p, 2.3 MB |
Global and Regional Deep Learning Models for Multiple Sclerosis Stratification From MRI
/
Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquin (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona) ;
Montalban, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona) ;
Tur, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: The combination of anatomical MRI and deep learning-based methods such as convolutional neural networks (CNNs) is a promising strategy to build predictive models of multiple sclerosis (MS) prognosis. [...]
2023 -  10.1002/jmri.29046
Journal of Magnetic Resonance Imaging
|
|
|
2.
|
|
13 p, 1.1 MB |
Immunotherapy for people with clinically isolated syndrome or relapsing-remitting multiple sclerosis : treatment response by demographic, clinical, and biomarker subgroups (PROMISE)-a systematic review protocol
/
Lehnert, Thomas (University Medical Center Hamburg-Eppendorf) ;
Röver, Christian (University Medical Center Göttingen) ;
Köpke, Sascha (University of Cologne) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Chard, Declan (University College London Hospitals) ;
Fittipaldo, Andrea V. (Istituto Ricerche Farmacologiche "Mario Negri" IRCCS) ;
Friede, Tim (University Medical Center Göttingen) ;
Heesen, Christoph (University Medical Center Hamburg-Eppendorf) ;
Rahn, Anne C. (University of Lübeck) ;
Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system with an increasing worldwide prevalence. Since 1993, more than 15 disease-modifying immunotherapies (DMTs) have been licenced and have shown moderate efficacy in clinical trials. [...]
2022 - 10.1186/s13643-022-01997-2
Systematic Reviews, Vol. 11 (july 2022)
|
|
|
3.
|
|
9 p, 628.7 KB |
Serum Levels of CXCL13 Are Associated With Teriflunomide Response in Patients With Multiple Sclerosis
/
Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pappolla, Agustin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gutierrez, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
BACKGROUND AND OBJECTIVES: To identify biomarkers associated with treatment response in patients with multiple sclerosis (MS) treated with the oral therapies teriflunomide, dimethyl fumarate (DMF), and fingolimod. [...]
2023 - 10.1212/NXI.0000000000200050
Neurology® neuroimmunology & neuroinflammation, Vol. 10 Núm. 1 (january 2023)
|
|
|
4.
|
|
12 p, 4.0 MB |
Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI
/
Coll, Llucia (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Alberich, Manel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Oliver, Arnau (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Lladó, Xavier (Universitat de Girona. Institut de recerca en visió per computador i robòtica (VICOROB)) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The application of convolutional neural networks (CNNs) to MRI data has emerged as a promising approach to achieving unprecedented levels of accuracy when predicting the course of neurological conditions, including multiple sclerosis, by means of extracting image features not detectable through conventional methods. [...]
2023 - 10.1016/j.nicl.2023.103376
NeuroImage, Vol. 38 (march 2023)
|
|
|
5.
|
|
9 p, 692.2 KB |
Increased NLRP3 Inflammasome Activation and Pyroptosis in Patients With Multiple Sclerosis With Fingolimod Treatment Failure
/
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hurtado-Navarro, Laura (Hospital Universitari Vall d'Hebron) ;
Pappolla, Agustin (Hospital Universitari Vall d'Hebron) ;
Villar, Luisa M. (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Pelegrín, Pablo (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Inflammasomes are involved in the pathogenesis of different neuroimmune and neurodegenerative diseases, including multiple sclerosis (MS). In a previous study by our group, the nucleotide-binding oligomerization domain, leucine-rich repeat receptor and pyrin-domain-containing 3 (NLRP3) inflammasome was reported to be associated with the response to interferon-beta in MS. [...]
2023 - 10.1212/NXI.0000000000200100
Neurology® neuroimmunology & neuroinflammation, Vol. 10 (march 2023)
|
|
|
6.
|
|
8 p, 871.8 KB |
Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis
/
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Zuluaga Rodas, María Isabel (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Marta (Hospital Universitari Vall d'Hebron) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To evaluate whether oral contraceptive (OC) use is associated with the risk of a second attack and disability accrual in women with a clinically isolated syndrome (CIS) and early multiple sclerosis (MS). [...]
2021 - 10.1177/13524585211053001
Multiple sclerosis, Vol. 28 (november 2021) , p. 950-957
|
|
|
7.
|
|
10 p, 509.3 KB |
Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
/
Tur, Carmen (Hospital Universitari Vall d'Hebron) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ;
Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron) ;
Salerno, Annalaura (Hospital Universitari Vall d'Hebron) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Río, Jordi (Hospital Universitari Vall d'Hebron) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis. What are the long-term outcomes of patients developing progression independent of relapse activity (PIRA) after a first demyelinating event in multiple sclerosis? In this longitudinal cohort study including 1128 patients with a first demyelinating event in multiple sclerosis, presenting with PIRA was associated with significantly shorter times to developing severe disability compared with not presenting with PIRA. [...]
2022 - 10.1001/jamaneurol.2022.4655
JAMA Neurology, Vol. 80 (december 2022) , p. 151-160
|
|
|
8.
|
|
11 p, 711.9 KB |
Transcription-based prediction of response to IFNbeta using supervised computational methods
/
Baranzini, Sergio E. (University of California, San Francisco) ;
Mousavi, Parvin (Queen's University, Kingston, Ontario) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron) ;
Caillier, Stacy J. (University of California, San Francisco) ;
Stillman, Althea (University of California, San Francisco) ;
Villoslada, Pablo (Clínica Universidad de Navarra) ;
Wyatt, Mathew M. (University of California, San Francisco) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Greller, Larry D. (Biosystemix, Sydenham, Ontario) ;
Somogyi, Roland (Biosystemix, Sydenham, Ontario) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (University of California, San Francisco)
Changes in cellular functions in response to drug therapy are mediated by specific transcriptional profiles resulting from the induction or repression in the activity of a number of genes, thereby modifying the preexisting gene activity pattern of the drug-targeted cell(s). [...]
2005 - 10.1371/journal.pbio.0030002
PLoS biology, Vol. 3 Núm. 1 (2005) , art. e2
|
|
|
9.
|
|
6 p, 333.0 KB |
Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab
/
Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pignolet, Beatrice (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vermersch, Patrick (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruet, Aurélie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
deSèze, Jerome (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Labauge, Pierre (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vukusic, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Papeix, Caroline (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Almoyna, Laurent (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tourbah, Ayman (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clavelou, Pierre (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moreau, Thibault (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pelletier, Jean (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lebrun-Frenay, Christine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bourre, Bertrand (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Defer, Gilles (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brassat, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The study aimed to assess the potential for serum neurofilament light chain (NFL) levels to predict the risk of progressive multifocal leukoencephalopathy (PML) in natalizumab (NTZ)-treated patients with multiple sclerosis (MS) and to discriminate PML from MS relapses. [...]
2021 - 10.1212/NXI.0000000000001003
Neurology® neuroimmunology & neuroinflammation, Vol. 8 (april 2021)
|
|
|
10.
|
|
6 p, 201.9 KB |
Pharmacogenomic study in patients with multiple sclerosis
/
Bustamante, Marta F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morcillo-Suarez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Leyva, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zettl, Uwe K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Killestein, Joep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brassat, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Merino, Juan Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Antonio J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Urcelay, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Lafuente, Roberto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Lusia M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Farré, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lechner-Scott, Jeannette (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vandenbroeck, Koen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Antigüedad, Alfredo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinelli Boneschi, Filippo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chan, Andrew (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Arcadi, 1969- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aimed to investigate the association between polymorphisms located in type I interferon (IFN)-induced genes, genes belonging to the toll-like receptor (TLR) pathway, and genes encoding neurotransmitter receptors and the response to IFN-β treatment in patients with multiple sclerosis (MS). [...]
2015 - 10.1212/NXI.0000000000000154
Neurology® neuroimmunology & neuroinflammation, Vol. 2 (september 2015)
|
|
visitant ::
identificació
alerta personal via correu electrònic o subscribiu-vos al 
canal RSS.
