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The INTERPRET Decision-Support System version 3.0 for evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses
Pérez Ruiz, Alexander (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Julià Sapé, Ma. Margarita (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Mercadal, Guillem (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Olier, Iván (Universitat Autònoma de Barcelona. Institut de Neurociències)
Majós, Carles (Institut de Diagnòstic per la Imatge)
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date: 2010
Abstract: Background: Proton Magnetic Resonance (MR) Spectroscopy (MRS) is a widely available technique for those clinical centres equipped with MR scanners. Unlike the rest of MR-based techniques, MRS yields not images but spectra of metabolites in the tissues. In pathological situations, the MRS profile changes and this has been particularly described for brain tumours. However, radiologists are frequently not familiar to the interpretation of MRS data and for this reason, the usefulness of decision-support systems (DSS) in MRS data analysis has been explored. Results: This work presents the INTERPRET DSS version 3. 0, analysing the improvements made from its first release in 2002. Version 3. 0 is aimed to be a program that 1st, can be easily used with any new case from any MR scanner manufacturer and 2nd, improves the initial analysis capabilities of the first version. The main improvements are an embedded database, user accounts, more diagnostic discrimination capabilities and the possibility to analyse data acquired under additional data acquisition conditions. Other improvements include a customisable graphical user interface (GUI). Most diagnostic problems included have been addressed through a pattern-recognition based approach, in which classifiers based on linear discriminant analysis (LDA) were trained and tested. Conclusions: The INTERPRET DSS 3. 0 allows radiologists, medical physicists, biochemists or, generally speaking, any person with a minimum knowledge of what an MR spectrum is, to enter their own SV raw data, acquired at 1. 5 T, and to analyse them. The system is expected to help in the categorisation of MR Spectra from abnormal brain masses.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: BMC Bioinformatics, Vol. 11 N. 581 (November 2010) , p. 1-12, ISSN 1471-2105

DOI: 10.1186/1471-2105-11-581
PMID: 21114820

12 p, 816.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles

 Record created 2014-10-09, last modified 2018-11-11

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