DCE@urLAB : a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data
Ortuño, Juan E. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Ledesma-Carbayo, María Jesús (Universidad Politécnica de Madrid. Departamento de Ingeniería Electrónica)
Simoes, Rui Vasco (Universitat de Barcelona)
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Santos, Andrés (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)

Date:	2013
Abstract:	Background: DCE@urLAB is a software application for analysis of dynamic contrast-enhanced magnetic resonance imaging data (DCE-MRI). The tool incorporates a friendly graphical user interface (GUI) to interactively select and analyze a region of interest (ROI) within the image set, taking into account the tissue concentration of the contrast agent (CA) and its effect on pixel intensity. Results: Pixel-wise model-based quantitative parameters are estimated by fitting DCE-MRI data to several pharmacokinetic models using the Levenberg-Marquardt algorithm (LMA). DCE@urLAB also includes the semi-quantitative parametric and heuristic analysis approaches commonly used in practice. This software application has been programmed in the Interactive Data Language (IDL) and tested both with publicly available simulated data and preclinical studies from tumor-bearing mouse brains. Conclusions: A user-friendly solution for applying pharmacokinetic and non-quantitative analysis DCE-MRI in preclinical studies has been implemented and tested. The proposed tool has been specially designed for easy selection of multi-pixel ROIs. A public release of DCE@urLAB, together with the open source code and sample datasets, is available at http://www. die. upm. es/im/archives/DCEurLAB/.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	DCE-MRI ; Imaging ; Levenberg-Marquardt ; Fitting ; Preclinical ; Pharmacokinetics ; Animal models ; High field MR ; IDL
Published in:	BMC bioinformatics, Vol. 14, N. 316 (November 2013) , p. 1-17, ISSN 1471-2105

DOI: 10.1186/1471-2105-14-316
PMID: 24180558

17 p, 2.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles