Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragmen
Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Rivera Hernández, Geovanny (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date:	2013
Abstract:	The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD cerebellum is described for the first time, together with its protection by scFv-h3D6. Neuron depletion in the DCN was regionally variable and followed a mediolateral axis of involvement that was greatest in the fastigial nucleus, lesser in the interpositus and negligible in the dentate nucleus. A sole and low intraperitoneal dose of scFv-h3D6 protected 3xTg-AD DCN neurons from death. Further studies might provide interesting information about both the potential of scFv-h3D6 as a therapeutic agent and the role of the cerebellum in AD.
Grants:	Instituto de Salud Carlos III FEDER/PI10/00975 Instituto de Salud Carlos III FEDER/PI10/00265 Instituto de Salud Carlos III FEDER/PI10/00283 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-00761 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-42271
Note:	This work was supported by FMM-2008; FEDER (FISPI10-00975, -00265 and -00283); SGR2009-00761 and -42271. G.R-H is supported by a MAEC-AECI fellowship (Spanish government) and G.E-C. by a PIF (UAB, Spain) fellowship.
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió sotmesa a revisió
Subject:	ScFv-h3D6 ; Immunotherapy ; Alzheimer disease ; Cerebellum ; DCN neurons
Published in:	MAbs, Vol. 5 Issue 5 (Sep.-Oct. 2013) , p. 660-664, ISSN 1942-0870

DOI: 10.4161/mabs.25428
PMID: 23884149

Pre-print 17 p, 1.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
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Articles > Published articles