Delineating the factors and cellular mechanisms involved in the survival of cerebellar granule neurons
Xifro Collsamata, Francesc Xavier (Universitat de Girona. Departament de Ciències Mèdiques)
Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)

Date:	2015
Abstract:	Cerebellar granule neurons (CGNs) constitute the most abundant neuronal population in the mammalian brain. Their postnatal generation and the feasibility to induce their apoptotic death in vitro make them an excellent model to study the effect of several neurotransmitters and neurotrophins. Here, we first review which factors are involved in the generation and proliferation of CGNs in the external granule layer (EGL) and in the regulation of their differentiation and migration to internal granule layer (IGL). Special attention was given to the role of several neurotrophins and the NMDA subtype of glutamate receptor. Then, using the paradigm of potassium deprivation in cultured CGNs, we address several extracellular factors that promote the survival of CGNs, with particular emphasis on the cellular mechanisms. The role of specific protein kinases leading to the regulation of transcription factors and recent data involving the small G protein family is also discussed. Finally, the participation of some members of Bcl-2 family and the inhibition of mitochondria-related apoptotic pathway is also considered. Altogether, these studies evidence that CGNs are a key model to understand the development and the survival of neuronal populations.
Grants:	Ministerio de Ciencia e Innovación SAF2011-30281 Instituto de Salud Carlos III CIBERNED/CB06/05/0042 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-1231 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-0984
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió acceptada per publicar
Subject:	Cerebellar granule neurons ; Development ; Differentiation ; Neuroprotection ; Survival pathways
Published in:	Cerebellum, Vol. 14, Num. 3 (June 2015) , ISSN 1473-4230

DOI: 10.1007/s12311-015-0646-z

Post-print 12 p, 211.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Published articles