Web of Science: 9 citations, Scopus: 10 citations, Google Scholar: citations,
Trisomy 8, a cytogenetic abnormality in Myelodysplastic Syndromes, is constitutional or not?
Saumell i Tutusaus, Sílvia (Universitat Autònoma de Barcelona. Departament de Medicina)
Solé Ristol, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Arenillas, Leonor (Hospital del Mar (Barcelona, Catalunya))
Montoro Gómez, Julia (Hospital Universitari Vall d'Hebron)
Valcarcel Ferreiras, David (Hospital Universitari Vall d'Hebron)
Pedro, Carme (Institut Hospital del Mar d'Investigacions Mèdiques)
Sanzo, Carmen (Hospital Universitario Central de Asturias (Oviedo))
Luño, Elisa (Hospital Universitario Central de Asturias (Oviedo))
Giménez, Teresa (Hospital Universitari Joan XXIII de Tarragona)
Arnan, Montserrat (Institut Català d'Oncologia)
Pomares, Helena (Institut Català d'Oncologia)
De Paz, Raquel (Hospital Universitario La Paz (Madrid))
Arrizabalaga, Beatriz (Hospital Universitario Cruces (Barakaldo, Biscaia))
Jerez, Andrés (Hospital General Universitario Morales Meseguer (Múrcia))
Martínez, Ana B. (Hospital General Universitario Morales Meseguer (Múrcia))
Sánchez-Castro, Judith (Hospital Universitari Arnau de Vilanova (Lleida, Catalunya))
Rodríguez-Gambarte, Juan D. (Hospital Universitario Ramón y Cajal (Madrid))
Raya, José M. (Hospital Universitario de Canarias (Santa Cruz de Tenerife))
Ríos, Eduardo (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Rodríguez-Rivera, María (Hospital del Mar (Barcelona, Catalunya))
Espinet i Solà, Blanca (Hospital del Mar (Barcelona, Catalunya))
Florensa, L. (Hospital del Mar (Barcelona, Catalunya))

Date: 2015
Abstract: Isolated trisomy 8 is not considered presumptive evidence of myelodysplastic syndrome (MDS) in cases without minimal morphological criteria. One reason given is that trisomy 8 (+8) can be found as a constitutional mosaicism (cT8M). We tried to clarify the incidence of cT8M in myeloid neoplasms, specifically in MDS, and the diagnostic value of isolated +8 in MDS. Twenty-two MDS and 10 other myeloid neoplasms carrying +8 were studied. Trisomy 8 was determined in peripheral blood by conventional cytogenetics (CC) and on granulocytes, CD3+ lymphocytes and oral mucosa cells by fluorescence in situ hybridization (FISH). In peripheral blood CC, +8 was seen in 4/32 patients. By FISH, only one patient with chronic myelomonocytic leukemia showed +8 in all cell samples and was interpreted as a cT8M. In our series +8 was acquired in all MDS. Probably, once discarded cT8M by FISH from CD3+ lymphocytes and non-hematological cells, +8 should be considered with enough evidence to MDS.
Grants: Instituto de Salud Carlos III FI07/00107
Instituto de Salud Carlos III CA08/00141
Instituto de Salud Carlos III PI07/1009
Instituto de Salud Carlos III PI11/02010
Instituto de Salud Carlos III RTICC/RD06/0020/0031
Instituto de Salud Carlos III RTICC/RD07/0020/2004
Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-541
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Acute myeloid leukemia ; Lymphocytes ; Cytogenetics ; Fluorescent in situ hybridization ; Granulocytes ; Neoplasms ; Cancer detection and diagnosis ; Leukemias
Published in: PloS one, Vol. 10, No 6 (June 2015) , p. e0129375, ISSN 1932-6203

DOI: 10.1371/journal.pone.0129375
PMID: 26066831

7 p, 184.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Research articles
Articles > Published articles

 Record created 2016-07-08, last modified 2021-09-05

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