Web of Science: 22 cites, Scopus: 24 cites, Google Scholar: cites,
Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation
Baron, Frédéric (Université de Liège (Bèlgica))
Labopin, Myriam (Hôpital Saint-Antoine (Paris, França))
Ruggeri, Annalisa (Hôpital Saint-Louis (Paris, França))
Mohty, Mohamad (Hôpital Saint-Antoine (Paris, França))
Sanz, Guillermo (Hospital Universitario y Politécnico La Fe (València, País Valencià))
Milpied, Noel (Hôpital Haut Léveque (Pessac, França))
Bacigalupo, Andrea (Ospedale Sant Martino (Genova, Itàlia))
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni XXIII (Bergamo, Itàlia))
Bonifazi, Francesca (Policlinico Sant'Orsola-Malpighi (Bologna, Itàlia))
Bosi, Alberto (Azienda Ospedaliero Universitaria Careggi (Firenze, Itàlia))
Sierra, Jorge (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Yakoub-Agha, Ibrahim (Hôpital Claude Huriez (Lille, França))
Ribera Santasusana, J. M. (José María) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Gluckman, Eliane (Hôpital Saint-Louis (Paris, França))
Nagler, Arnon (Sheba Medical Center (Ramat Gran, Israel))

Data: 2015
Resum: BACKGROUND: In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). The aim of the current analysis was to compare transplantation outcomes in male patients given female unrelated cord blood (UCB) versus other gender combinations. PATIENTS AND METHODS: Data from 552 consecutive patients with acute myeloid leukemia (AML) given a single UCB transplantation between 2000 and 2014 were included. RESULTS:In comparison with other gender combination, male patients given female UCB (n = 131) had a trend for a higher incidence of grades II-IV acute GVHD (33 versus 25 %, P = 0. 08), a trend for a higher incidence of NRM (41 versus 33 %, P = 0. 06), and a lower leukemia-free (LFS, 30 versus 41 %, P = 0. 01) and overall survival (OS, 33 versus 45 %, P = 0. 008). In multivariate analyses, taking into consideration all patients for which data on HLA-matching and cell dose transplanted were fully available (n = 363), male patients transplanted with a female UCB had a trend for a higher incidence of grade III-IV acute GVHD (hazard ratio (HR) = 2. 0, P = 0. 06), a trend for a higher NRM (HR = 1. 5, P = 0. 06), and a worse LFS (HR = 1. 4, P = 0. 04) and OS (HR = 1. 3, P = 0. 06). CONCLUSIONS: Our data suggest that male patients transplanted with female UCB might have higher risk of acute GVHD and of NRM leading to worse LFS and OS. These results should be confirmed in other large cohorts of patients before used for determining the choice of an UCB unit.
Nota: Ajuts: National Fund for Scientific Research (FNRS) Belgium
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Sang fetal ; Unrelated cord blood ; Female ; Male ; AML ; GVHD ; Transplantation
Publicat a: Journal of hematology & oncology, Vol. 8 Núm. 107 (october 2015) , ISSN 1756-8722

DOI: 10.1186/s13045-015-0207-4
PMID: 26445106


11 p, 858.6 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
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 Registre creat el 2016-07-25, darrera modificació el 2018-10-27



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