Chromosomal bands affected by acute oil exposure and DNA repair errors
Monyarch Gros, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
de Castro Reis, Fernanda (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Zock, Jan-Paul (Centre de Recerca en Epidemiologia Ambiental)
Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Pozo Rodríguez, Francisco (Hospital Universitario 12 de Octubre (Madrid))
Espinosa, Ana (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Rodríguez-Trigo, Gema (Hospital Clínico San Carlos (Madrid))
Verea, Hector (Complejo Hospitalario Universitario de A Coruña)
Castaño-Vinyals, Gemma (Hospital del Mar (Barcelona, Catalunya))
Gómez, Federico P. (Hospital Clínic i Provincial de Barcelona)
Antó i Boqué, Josep Maria (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Coll, Maria Dolors (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Barberà i Mir, Joan Albert (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Fuster i Marquès, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Data:	2013
Resum:	Background: In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk. Objectives: We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency. Methods: Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin. Results: Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0. 016). Conclusion: The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 8, Num. 11 (2013) , p. 1-7, ISSN 1932-6203

DOI: 10.1371/journal.pone.0081276
PMID: 24303039

7 p, 453.8 KB

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