Home > Articles > Published articles > BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS |
Date: | 2015 |
Abstract: | The increasing incidence of diseases affecting the central nervous system (CNS) demands the urgent development of efficient drugs. While many of these medicines are already available, the Blood Brain Barrier and to a lesser extent, the Blood Spinal Cord Barrier pose physical and biological limitations to their diffusion to reach target tissues. Therefore, efforts are needed not only to address drug development but specially to design suitable vehicles for delivery into the CNS through systemic administration. In the context of the functional and structural versatility of proteins, recent advances in their biological fabrication and a better comprehension of the physiology of the CNS offer a plethora of opportunities for the construction and tailoring of plain nanoconjugates and of more complex nanosized vehicles able to cross these barriers. We revise here how the engineering of functional proteins offers drug delivery tools for specific CNS diseases and more transversally, how proteins can be engineered into smart nanoparticles or 'artificial viruses' to afford therapeutic requirements through alternative administration routes. |
Grants: | Fundació la Marató de TV3 2011-110533 Fundació la Marató de TV3 2013-133930 Fundació la Marató de TV3 2013-132031 Ministerio de Economía y Competitividad BIO2013-41019-P Instituto de Salud Carlos III FI09/00150 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Language: | Anglès |
Document: | Article de revisió ; Article ; Versió acceptada per publicar |
Subject: | Nanoparticles ; BBB ; Protein engineering ; Recombinant proteins ; Artificial viruses ; Drug delivery ; Gene therapy |
Published in: | Biotechnology advances, Vol. 33 Núm. 2(Març-Abril 2015) , p. 277-287, ISSN 0734-9750 |
Postprint 38 p, 1.1 MB |
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