Predictors of severe sepsis among patients hospitalized for community-acquired pneumonia
Montull Veiga, Beatriz (Hospital Universitari i Politècnic La Fe (València))
Menéndez Villanueva, Rosario (Hospital Universitari i Politècnic La Fe (València))
Torres, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Reyes Calzada, Soledad María (Hospital Universitari i Politècnic La Fe (València))
Méndez, Raúl (Hospital Universitari i Politècnic La Fe (València))
Zalacaín, Rafael (Hospital Universitario de Cruces (Barakaldo, País Basc))
Capelastegui, Alberto (Hospital de Galdakao (Usansolo, Biscaia))
Rajas, Olga (Hospital Universitario de la Princesa (Madrid))
Borderías, Luis (Hospital General Universitario San Jorge (Osca, Aragó))
Martín Villasclaras, Juan (Hospital Regional Universitario de Málaga)
Bello, Salvador (Hospital Universitario Miguel Servet (Saragossa))
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia))
Rodríguez de Castro, Felipe (Hospital Universitario de Gran Canaria Dr. Negrín)
Rello, Jordi (Hospital Universitari Joan XXIII de Tarragona)
Molinos, Luis (Hospital Universitario Central de Asturias)
Ruiz Manzano, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2016
Abstract:	Background: Severe sepsis, may be present on hospital arrival in approximately one-third of patients with community-acquired pneumonia (CAP). Objective: To determine the host characteristics and micro-organisms associated with severe sepsis in patients hospitalized with CAP. Results: We performed a prospective multicenter cohort study in 13 Spanish hospital, on 4070 hospitalized CAP patients, 1529 of whom (37. 6%) presented with severe sepsis. Severe sepsis CAP was independently associated with older age (>65 years), alcohol abuse (OR, 1. 31; 95% CI, 1. 07-1. 61), chronic obstructive pulmonary disease (COPD) (OR, 1. 75; 95% CI, 1. 50-2. 04) and renal disease (OR, 1. 57; 95% CI, 1. 21-2. 03), whereas prior antibiotic treatment was a protective factor (OR, 0. 62; 95% CI, 0. 52-0. 73). Bacteremia (OR, 1. 37; 95% CI, 1. 05-1. 79), S pneumoniae (OR, 1. 59; 95% CI, 1. 31-1. 95) and mixed microbial etiology (OR, 1. 65; 95% CI, 1. 10-2. 49) were associated with severe sepsis CAP. Conclusions: CAP patients with COPD, renal disease and alcohol abuse, as well as those with CAP due to S pneumonia or mixed micro-organisms are more likely to present to the hospital with severe sepsis.
Grants:	Instituto de Salud Carlos III PI04/1150
Note:	This work was supported by PII (Programme of research of SEPAR) in respiratory infection; CIBERES (Centro de investigación en red de enfermedades respiratorias) an initiative of ISCIII (Instituto de Salud Carlos III); Beca Fis (PI04/1150); Beca SEPAR (Sociedad Española de Neumología y Cirugía torácica) (2006/0237) and Beca de la Consellería Sanitat Comunidad Valenciana (2007/ 0059).
Note:	Altres ajuts: SEPAR/2006/0237
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Community-acquired pneumonia ; Predictors ; Severe sepsis
Published in:	PloS one, Vol. 11 Núm. 1 (January 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0145929
PMID: 26727202

9 p, 190.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles