Predictors of human papillomavirus infection in women undergoing routine cervical cancer screening in Spain : the CLEOPATRE study
Roura, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Iftner, Thomas (University Hospital of Tübingen (Alemanya))
Vidart, José Antonio (Hospital Clínico San Carlos (Madrid))
Kjaer, Susanne Krüger (Copenhagen University Hospital Rigshospitalet)
Bosch José, Francesc Xavier 1947- (Institut Germans Trias i Pujol)
Muñoz, Nubia (National Cancer Institute (Bogotà, Colòmbia))
Palacios, Santiago (Instituto Palacios. Salud y Medicina de la Mujer (Madrid, Espanya))
Rodriguez, Maria San Martin (Medical Department, Sanofi Pasteur MSD, Madrid, Spain)
Morillo, Carmen (Medical Department, Sanofi Pasteur MSD, Madrid, Spain)
Serradell, Laurence (Epidemiology Department, Sanofi Pasteur MSD, Lyon, France)
Torcel-Pagnon, Laurence (Epidemiology Department, Sanofi Pasteur MSD, Lyon, France)
Cortés, Javier (Senior Consultant in Gynaecology Oncology, Spanish Society of Obstetrics and Gynaecology, Palma de Mallorca, Islas Baleares, Spain)
Castellsagué, Xavier (Institut Germans Trias i Pujol)

Data:	2012
Resum:	Human papillomavirus (HPV) is a sexually transmitted infection that may lead to development of precancerous and cancerous lesions of the cervix. The aim of the current study was to investigate socio-demographic, lifestyle, and medical factors for potential associations with cervical HPV infection in women undergoing cervical cancer screening in Spain. The CLEOPATRE Spain study enrolled 3 261 women aged 18-65 years attending cervical cancer screening across the 17 Autonomous Communities. Liquid-based cervical samples underwent cytological examination and HPV testing. HPV positivity was determined using the Hybrid Capture II assay, and HPV genotyping was conducted using the INNO-LiPA HPV Genotyping Extra assay. Multivariate logistic regression was used to identify putative risk factors for HPV infection. A lifetime number of two or more sexual partners, young age (18-25 years), a history of genital warts, and unmarried status were the strongest independent risk factors for HPV infection of any type. Living in an urban community, country of birth other than Spain, low level of education, and current smoking status were also independent risk factors for HPV infection. A weak inverse association between condom use and HPV infection was observed. Unlike monogamous women, women with two or more lifetime sexual partners showed a lower risk of infection if their current partner was circumcised (P for interaction, 0. 005) and a higher risk of infection if they were current smokers (P for interaction, 0. 01). This is the first large-scale, country-wide study exploring risk factors for cervical HPV infection in Spain. The data strongly indicate that variables related to sexual behavior are the main risk factors for HPV infection. In addition, in non-monogamous women, circumcision of the partner is associated with a reduced risk and smoking with an increased risk of HPV infection.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	HPV infection ; Prevalence ; Risk factors ; Sexual behavior ; Questionnaire ; Spain
Publicat a:	BMC Infectious diseases, Vol. 12 (june 2012) , p. 145, ISSN 1471-2334

DOI: 10.1186/1471-2334-12-145
PMID: 22734435

13 p, 297.5 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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