Interleukin-6, a Major Cytokine in the Central Nervous System
Erta Cañabate, Maria (Universitat Autònoma de Barcelona. Institut de Neurociències)
Quintana Romero, Albert (University of Washington. Departament of Chemistry)
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències)
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Date:	2012
Abstract:	Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell differentiation factor, capable of inducing the maturation of B cells into antibody-producing cells. As with many other cytokines, it was soon realized that IL-6 was not a factor only involved in the immune response, but with many critical roles in major physiological systems including the nervous system. IL-6 is now known to participate in neurogenesis (influencing both neurons and glial cells), and in the response of mature neurons and glial cells in normal conditions and following a wide arrange of injury models. In many respects, IL-6 behaves in a neurotrophin-like fashion, and seemingly makes understandable why the cytokine family that it belongs to is known as neuropoietins. Its expression is affected in several of the main brain diseases, and animal models strongly suggest that IL-6 could have a role in the observed neuropathology and that therefore it is a clear target of strategic therapies.
Grants:	Ministerio de Ciencia e Innovación SAF2008-00435 Ministerio de Ciencia e Innovación SAF2011-23272 Instituto de Salud Carlos III RD07-0060-0002 Ministerio de Ciencia e Innovación 2008-0671
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Neuropoietin ; Neuroinflammation ; Neurogenesis ; Gliogenesis ; Alzheimer's disease ; Multiple sclerosis ; Stroke ; Trauma
Published in:	International journal of biological sciences, Vol. 8, Num. 9 (2012) , p. 1254-1266, ISSN 1449-2288

DOI: 10.7150/ijbs.4679
PMID: 23136554

13 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles