The epidermal growth factor receptor (EGRF) in lung cancer
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Capdevila, Laia (Hospital Sant Pau i Santa Tecla (Tarragona))
Cros Costa, Sara (Hospital General de Granollers)
Vilà, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
de los Llanos Gil, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Remón, Jordi (Hospital de Mataró. Consorci Sanitari del Maresme)
Rosell, Rafael (Fundación Molecular Oncology Research)
Universitat Autònoma de Barcelona

Date:	2015
Abstract:	In the last decade, important advances have been made in understanding of cancer biology, particularly non-small-cell lung cancer (NSCLC) with the discovery of oncogenic drivers of the disease. The epidermal growth factor receptor (EGFR) gene and its pathways was the first oncogenic driver discovered to be mutated and treatable in lung cancer. Treatment with EGFR tyrosine kinase inhibitors (TKIs) is the standard of care for molecularly selected EGFR -mutant patients, while its role in unselected lung cancer patients is nowadays controversial. This review will provide an overview of the EGFR pathway and options for its treatment of lung cancer.
Note:	Altres ajuts: Work in Dr Rosell's laboratory is partially supported by a grant from Fundació La Caixa
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Lung cancer ; Epidermal growth factor receptor ; EGFR ; Tyrosine kinase inhibitors ; TKI
Published in:	Translational Respiratory Medicine, Vol. 3 (february 2015) , ISSN 2213-0802

DOI: 10.1186/s40247-015-0013-z
PMID: 25810955

8 p, 738.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles