Editorial - Glial Cells : Managers of Neuro-Immunity
Barcia, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències)
Guillemin, Gilles J. (Macquarie University. Department of Biomedical Sciences)
Curtin, James (Dublin Institute of Technology. School of Food Science & Environmental Health)
Zirger, Jeffrey M. (U.S. Centers for Disease Control and Prevention)
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Fecha:	2016
Resumen:	After many decades of study in the field of Neuroscience that were mostly centered on the neuron there is a mounting interest in the study of the function of the glial cells in many aspects and functions of the central nervous system. The involvement of glial cells in neuroimmunity is one of the critical pieces within this puzzle, and one that entails great complexity. An increasing number of publications shows that resident astroglia and microglia are the real managers of immune responses, orchestrating chemokine and cytokine release, blood cell infiltration, and promotion of angiogenesis, etc. Moreover, each disease and neuroinflammatory scenario seems to have its own distinct biochemical characteristics and glial phenotype. Classical definitions of resting and activated microglial cells or pro-inflammatory and anti-inflammatory phenotypes are recognized today as oversimplified models of glial cell functions and have since been surpassed by more defined and precise characterizations. The present Frontiers Research Topic (FRT) is a great example of this, since the study of different scenarios reflects diverse modes of glial activation and distinct complexities.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Glia ; Neuroinflammation ; Neuroimmunology ; Microglia ; Astroglia ; T cells
Publicado en:	Frontiers in cellular neuroscience, Vol. 10 (March 2016) , art.60, ISSN 1662-5102

DOI: 10.3389/fncel.2016.00060
PMID: 27047335

2 p, 165.1 KB

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