Effects of sardine-enriched diet on metabolic control, inflammation and gut microbiota in drug-naïve patients with type 2 diabetes : a pilot randomized trial
Balfegó, Mariona (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Canivell, S.. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Hanzu, Felicia A. (Hospital Clínic i Provincial de Barcelona)
Sala Vila, Aleix (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Martínez Medina, Margarita (Universitat de Girona. Laboratori de Microbiologia Molecular)
Murillo, Serafín (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Mur, Teresa (Mútua de Terrassa. Centre d'Atenció Primària de Terrassa Sud)
Ruano, Elena G. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Linares, Francisca (Instituto de Investigación Biomédica de Málaga)
Porras, Nuria (Instituto de Investigación Biomédica de Málaga)
Valladares, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fontalba, Maria (Instituto de Investigación Biomédica de Málaga)
Roura, Elena (Fundació Alícia (Sant Fruitós del Bages - Barcelona))
Novials, Anna (Hospital Clínic i Provincial de Barcelona)
Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Aranda, Gloria (Hospital Clínic i Provincial de Barcelona)
Sisó Almirall, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Rojo Martínez, Gemma (Instituto de Investigación Biomédica de Málaga)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gomis, Ramon (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Data:	2016
Resum:	Nutrition therapy is the cornerstone of treating diabetes mellitus. The inclusion of fish (particularly oily fish) at least two times per week is recommended by current international dietary guidelines for type 2 diabetes. In contrast to a large number of human studies examining the effects of oily fish on different cardiovascular risk factors, little research on this topic is available in patients with type 2 diabetes. The aims of this pilot study were to investigate the effects of a sardine-enriched diet on metabolic control, adiponectin, inflammatory markers, erythrocyte membrane fatty acid (EMFA) composition, and gut microbiota in drug-naïve patients with type 2 diabetes. 35 drug-naïve patients with type 2 diabetes were randomized to follow either a type 2 diabetes standard diet (control group: CG), or a standard diet enriched with 100 g of sardines 5 days a week (sardine group: SG) for 6 months. Anthropometric, dietary information, fasting glycated hemoglobin, glucose, insulin, adiponectin, inflammatory markers, EMFA and specific bacterial strains were determined before and after intervention. There were no significant differences in glycemic control between groups at the end of the study. Both groups decreased plasma insulin (SG: −35. 3 %, P = 0. 01, CG: −22. 6 %, P = 0. 02) and homeostasis model of assessment - insulin resistance (HOMA-IR) (SG: −39. 2 %, P = 0. 007, CG: −21. 8 %, P = 0. 04) at 6-months from baseline. However only SG increased adiponectin in plasma compared to baseline level (+40. 7 %, P = 0. 04). The omega-3 index increased 2. 6 % in the SG compared to 0. 6 % in the CG (P = 0. 001). Both dietary interventions decreased phylum Firmicutes (SG and CG: P = 0. 04) and increased E. coli concentrations (SG: P = 0. 01, CG: P = 0. 03) at the end of the study from baseline, whereas SG decreased Firmicutes/Bacteroidetes ratio (P = 0. 04) and increased Bacteroides-Prevotella (P = 0. 004) compared to baseline. Although enriching diet with 100 g of sardines 5 days a week during 6 months to a type 2 diabetes standard diet seems to have neutral effects on glycemic control in drug-naïve patients with type 2 diabetes, this nutritional intervention could have beneficial effects on cardiovascular risk. Furthermore, both dietary interventions decreased HOMA-IR and altered gut microbiota composition of drug-naïve patients with type 2 diabetes.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-659
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Type 2 diabetes ; Pilot trial ; Nutrition therapy ; Oily fish ; Sardine
Publicat a:	Lipids in Health and Disease, Vol. 15 (April 2016) , art.78, ISSN 1476-511X

DOI: 10.1186/s12944-016-0245-0
PMID: 27090218

11 p, 782.5 KB

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