Web of Science: 37 cites, Scopus: 86 cites, Google Scholar: cites,
High throughput toxicity screening and intracellular detection of nanomaterials
Collins, Andrew R. (Universitetet i Oslo. Avdeling for ernæringsvitenskap)
Annangi, Balasubramanyam (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Rubio, Laura (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Dorn, Marco (Universität Leipzig. Institut für Medizinische Physik und Biphysik)
Merker, Carolin (Universität Leipzig. Institut für Medizinische Physik und Biphysik)
Estrela-Lopis, Irina (Universität Leipzig. Institut für Medizinische Physik und Biphysik)
Cimpan, Mihaela Roxana (Universitetet i Bergen. Det medisinske fakultet)
Ibrahim, Mohamed (Universitetet i Bergen. Det medisinske fakultet)
Cimpan, Emil (Høgskulen på Vestlandet)
Ostermann, Melanie (Universitetet i Bergen. Det medisinske fakultet)
Sauter, Alexander (Universitetet i Bergen. Det medisinske fakultet)
Yamani, Naouale El (Universitetet i Oslo. Avdeling for ernæringsvitenskap)
Shaposhnikov, Sergey (Universitetet i Oslo. Avdeling for ernæringsvitenskap)
Chevillard, Sylvie (Commissariat à l'Énergie Atomique et aux Énergies Alternatives (França))
Paget, Vincent (Commissariat à l'Énergie Atomique et aux Énergies Alternatives (França))
Grall, Romain (Commissariat à l'Énergie Atomique et aux Énergies Alternatives (França))
Delic, Jozo (Commissariat à l'Énergie Atomique et aux Énergies Alternatives (França))
Goñi-de-Cerio, Felipe (Gaiker, Centro Tecnológico)
Suarez-Merino, Blanca (Gaiker, Centro Tecnológico)
Fessard, Valérie (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (France)
Hogeveen, Kevin N. (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (France)
Fjellsbø, Lise Maria (Norsk institutt for luftforskning)
Pran, Elise Runden (Norsk institutt for luftforskning)
Brzicova, Tana (Ústav experimentální medicíny AV ČR, v. v. i.)
Topinka, Jan (Ústav experimentální medicíny AV ČR, v. v. i.)
Silva, Maria João (Instituto Nacional de Saúde Dr. Ricardo Jorge)
Leite, P. E. (Instituto Nacional de Metrologia, Calidad y Tecnología (Brasil))
Ribeiro, A. R. (Instituto Nacional de Metrologia, Calidad y Tecnología (Brasil))
Granjeiro, J. M. (Instituto Nacional de Metrologia, Calidad y Tecnología (Brasil))
Grafström, Roland (Karolinska Institutet (Estocolm, Suècia). Institute of Environmental Medicine)
Prina-Mello, Adriele (Trinity Centre for Health Sciences)
Dusinska, Maria (Norsk institutt for luftforskning)

Data: 2017
Resum: With the growing numbers of nanomaterials (), there is a great demand for rapid and reliable ways of testing safety-preferably using in vitro approaches, to avoid the ethical dilemmas associated with animal research. Data are needed for developing intelligent testing strategies for risk assessment of , based on grouping and read-across approaches. The adoption of high throughput screening () and high content analysis () for toxicity testing allows the testing of numerous materials at different concentrations and on different types of cells, reduces the effect of inter-experimental variation, and makes substantial savings in time and cost. / approaches facilitate the classification of key biological indicators of -cell interactions. Validation of in vitro tests is required, taking account of relevance to results. / approaches are needed to assess dose- and time-dependent toxicity, allowing prediction of adverse effects. Several / methods are being validated and applied for testing in the project , including Label-free cellular screening of uptake, HCA, High throughput flow cytometry, Impedance-based monitoring, Multiplex analysis of secreted products, and genotoxicity methods-namely High throughput comet assay, High throughput in vitro micronucleus assay, and assay. There are several technical challenges with / for testing, as toxicity screening needs to be coupled with characterization of in exposure medium prior to the test; possible interference of with / techniques is another concern. Advantages and challenges of / approaches in safety are discussed.
Ajuts: European Commission 310584
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Publicat a: Wiley interdisciplinary reviews. Nanomedicine and Nanobiotechnology, Vol. 9, issue 1 (Jan./Feb. 2017) , e1413, ISSN 1939-0041

DOI: 10.1002/wnan.1413
PMID: 27273980


30 p, 6.3 MB

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