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| Pàgina inicial > Articles > Articles publicats > Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients |
(Hospital Universitari Vall d'Hebron) (Hospital Universitari Vall d'Hebron) (Hospital Sant Joan de Déu (Barcelona, Catalunya)) (Instituto de Salud Carlos III) (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))| Data: | 2016 |
| Resum: | To assess the safety and efficacy of rilpivirine in combination with emtricitabine and tenofovir (RPV/FTC/TDF) as a once-daily single-tablet regimen (STR) in HIV-1-infected children and adolescents we performed a multicenter case series study of HIV-1-infected patients. Inclusion criteria were initiation of therapy with RPV/FTC/TDF before the age of 18. Patients were divided into undetectable viral load (uVL) group, HIV-1 RNA < 20 copies/mL on stable combined antiretroviral therapy (cART), and detectable viral load (dVL) group, HIV-1 RNA ≥ 20 copies/mL at RPV/FTC/TDF initiation. Patients were monitored from the date of RPV/FTC/TDF initiation until June 30, 2015, RPV/FTC/TDF discontinuation or failure to follow-up. Seventeen patients (8 in uVL and 9 in dVL group) with age between 11. 6 and 17. 6 were included. Reasons for switching were toxicity (n = 4) and simplification (n = 4) in uVL; viral failure (n = 8) and cART initiation (n = 1) in the dVL group. After a median follow-up of 90 (uVL) and 40 weeks (dVL), 7/8 (86%) patients maintained and 8/9 (89%) achieved and maintained HIV-1 suppression. Median CD4 count increased from 542 to 780/μL (uVL, P = 0. 069) and 480 to 830/μL (dVL, P = 0. 051). Five patients (2 in uVL and 3 in dVL) improved their immunological status from moderate to no immunosuppression. Serum lipid profiles improved in both groups; cholesterol dropped significantly in the dVL group (P = 0. 008). Grade 1 laboratory adverse events (AEs) were observed in 3 patients. No clinical AEs occurred. Adherence was complete in 9 patients (5 in uVL and 4 in dVL); 1 adolescent interrupted treatment. Once-daily STR with RPV/FTC/TDF may be a safe and effective choice in selected HIV-1-infected adolescents and children. |
| Ajuts: | Instituto de Salud Carlos III CP13-00098 Instituto de Salud Carlos III RD06-006 Instituto de Salud Carlos III RD12-0017-0035 Instituto de Salud Carlos III RD12-0017-0037 Instituto de Salud Carlos III MPY1039-14 |
| Nota: | Altres ajuts: Financial support was provided by FIPSE (grant number: 36-0910-10). CP is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (grant number SFRH/BPD/77448/2011, part of the EDCTP2 program supported by the European Union). |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Adolescents ; Antiretroviral therapy ; Children ; HIV-1 ; Rilpivirine |
| Publicat a: | Medicine, Vol. 95 (june 2016) , ISSN 1536-5964 |
