Pulmonary eosinophilia associated to treatment with natalizumab
Curto Sánchez, Elena (Institut Hospital del Mar d'Investigacions Mèdiques)
Munteis-Olivas, Elvira (Institut Hospital del Mar d'Investigacions Mèdiques)
Balcells, Eva (Institut Hospital del Mar d'Investigacions Mèdiques)
Institut Hospital del Mar d'Investigacions Mèdiques
Universitat Autònoma de Barcelona

Data:	2016
Resum:	Natalizumab (Tysabri ®) is a leukocytes chemotaxis inhibitor that decreases the leukocytes passage through the hematoencephalic barrier and it is currently used in relapsing-remitting forms of multiple sclerosis (MS). We present a patient with allergic rhinoconjunctivitis diagnosed with MS who started treatment with natalizumab. She began to show mild asthmatic symptoms until she needed admission to the hospital due to respiratory insufficiency. Blood tests showed peripheral eosinophilia and the thoracic computed tomography scan demonstrated pulmonary infiltrates. The bronchoscopy with the bronchoalveolar lavage resulted in eosinophilic alveolitis. No evidence of bacterial, fungal and parasitic infection, connective tissue disease, or vasculitis were observed. After discontinuation of natalizumab, the patient improved without other treatments. As MS is a prevalent disease and the use of natalizumab is increasing, we consider important to point out that this drug can be associated with pulmonary eosinophilia, especially in patients with allergic rhinoconjunctivitis or asthma.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Multiple sclerosis ; Natalizumab ; Pulmonary eosinophilia
Publicat a:	Annals of Thoracic Medicine, Vol. 11 (2016) , p. 224-226, ISSN 1998-3557

DOI: 10.4103/1817-1737.185762
PMID: 27512514

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