Web of Science: 18 cites, Scopus: 18 cites, Google Scholar: cites,
Circadian variation in acute myocardial infarct size assessed by cardiovascular magnetic resonance in reperfused STEMI patients
Bulluck, Heerajnarain (National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore)
Nicholas, Jennifer (London School Hygiene and Tropical Medicine, London, UK)
Crimi, Gabriele (Struttura Complessa Cardiologia, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy)
White, Steven K (The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK)
Ludman, Andrew J (Royal Devon & Exeter Hospital (Exeter, Regne Unit))
Pica, Silvia (Struttura Complessa Cardiologia, Azienda Ospedaliera SS: Antonio e Biagio, Alessandria, Italy)
Raineri, Claudia (Struttura Complessa Cardiologia, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia)
Cabrera-Fuentes, Hector A (Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore)
Yellon, Derek (The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London)
Rodriguez-Palomares, Jose (Hospital Universitari Vall d'Hebron)
García-Dorado, David (Hospital Universitari Vall d'Hebron)
Hausenloy, Derek J (Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore)
Universitat Autònoma de Barcelona

Data: 2017
Resum: Clinical studies using serum cardiac biomarkers to investigate a circadian variation in acute myocardial infarct (MI) size in ST-segment elevation myocardial infarction (STEMI) patients reperfused by primary percutaneous coronary intervention (PPCI) have produced mixed results. We aimed to investigate this phenomenon using acute MI size measured by cardiovascular magnetic resonance (CMR). Patient-level data was obtained from 4 randomized controlled trials investigating the MI-limiting effects of cardioprotective therapies in this pooled analysis. The primary analysis was performed in those patients with no pre-infarct angina; duration of ischemia > 60 min and < 360 min; Thrombolysis In Myocardial Infarction (TIMI) flow pre-PPCI ≤ 1; TIMI flow post-PPCI 3; and no collateral flow. 169 out of 376 patients with CMR data met the inclusion criteria for the primary analysis. A 24-hour circadian variation in acute MI size as a % of the area-at-risk (%AAR), after adjusting for confounders, was observed with a peak and nadir MI size in patients with symptom onset between 00:00 and 01:00 and between 12:00 and 13:00 respectively (difference from the average MI size 5. 2%, 95%CI 1. 1-9. 4%; p = 0. 013). This was associated with a non-significant circadian variation in left ventricular ejection fraction (LVEF) (difference from the average LVEF 5. 9%, 95%CI − 0. 6-2. 2%, p = 0. 073). There was no circadian variation in MI size or LVEF in the whole cohort. We report a circadian variation in acute MI size assessed by CMR in a subset of STEMI patients treated by PPCI, with the largest and smallest MI size occurring in patients with symptom onset between 00:00 and 01:00 and between 12:00 and 13:00 respectively.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: ST-segment elevation myocardial infarction ; Circadian rhythm ; Myocardial infarct size ; Cardiovascular magnetic resonance
Publicat a: International Journal of Cardiology, Vol. 230 (march 2017) , p. 149-154, ISSN 1874-1754

DOI: 10.1016/j.ijcard.2016.12.030
PMID: 28038815


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 Registre creat el 2018-02-08, darrera modificació el 2022-05-17



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