Web of Science: 17 cites, Scopus: 17 cites, Google Scholar: cites,
Bullseye's representation of cerebral white matter hyperintensities
Sudre, C.H. (Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG London, UK)
Gómez Ansón, Beatriz. (Institut d'Investigació Biomèdica Sant Pau)
Davagnanam, I. (University College London. Institute of Neurology)
Schmitt, A. (Lysholm Department of Neuroradiology, The National Hospital for Neurology and Neurosurgery, Queen Square, WCN1 3BG London, UK)
Mendelson, A.F. (Translational Imaging Group, CMIC, Department of Medical Physics and Biomedical Engineering, University College London, Room 8.04 8th floor Malet Place Engineering Building, 2, Malet Place, WC1E 7JE London, UK)
Prados, F. (Translational Imaging Group, CMIC, Department of Medical Physics and Biomedical Engineering, University College London, Room 8.04 8th floor Malet Place Engineering Building, 2, Malet Place, WC1E 7JE London, UK)
Smith, L. (Institute of Cardiovascular Science (Londres, Regne Unit))
Atkinson, D. (Centre for Medical Imaging, UCL Faculty of Medical Science, NW1 2PG London, UK)
Hughes, A.D. (Institute of Cardiovascular Science (Londres, Regne Unit))
Chaturvedi, N. (Institute of Cardiovascular Science (Londres, Regne Unit))
Cardoso, M.J. (Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG London, UK)
Barkhof, F. (University College London. Institute of Neurology)
Jaeger, H.R. (University College London. Institute of Neurology)
Ourselin, S. (Dementia Research Centre, UCL Institute of Neurology, WC1N 3BG London, UK)
Universitat Autònoma de Barcelona

Data: 2018
Resum: Visual rating scales have limited capacities to depict the regional distribution of cerebral white matter hyperintensities (WMH). We present a regional-zonal volumetric analysis alongside a visualization tool to compare and deconstruct visual rating scales. 3D T1-weighted, T2-weighted spin-echo and FLAIR images were acquired on a 3 T system, from 82 elderly participants in a population-based study. Images were automatically segmented for WMH. Lobar boundaries and distance to ventricular surface were used to define white matter regions. Regional-zonal WMH loads were displayed using bullseye plots. Four raters assessed all images applying three scales. Correlations between visual scales and regional WMH as well as inter and intra-rater variability were assessed. A multinomial ordinal regression model was used to predict scores based on regional volumes and global WMH burdens. On average, the bullseye plot depicted a right-left symmetry in the distribution and concentration of damage in the periventricular zone, especially in frontal regions. WMH loads correlated well with the average visual rating scores (e. g. Kendall's tau [Volume, Scheltens] = 0. 59 CI = [0. 53 0. 62]). Local correlations allowed comparison of loading patterns between scales and between raters. Regional measurements had more predictive power than global WMH burden (e. g. frontal caps prediction with local features: ICC = 0. 67 CI = [0. 53 0. 77], global volume = 0. 50 CI = [0. 32 0. 65], intra-rater = 0. 44 CI = [0. 23 0. 60]). Regional-zonal representation of WMH burden highlights similarities and differences between visual rating scales and raters. The bullseye infographic tool provides a simple visual representation of regional lesion load that can be used for rater calibration and training.
Ajuts: European Commission 601055
Nota: Altres ajuts: Carole H. Sudre is funded by the Wolfson Foundation , UCL Faculty of EngineeringMRC (MR/M023664/1), EPSRC (EP/M020533/1), the NIHR Biomedical Research Centre (BRC345/NS/SB/101410) and Alzheimer's Society(AS-JF-17-011). Sebastien Ourselin receives funding from the EPSRC (EP/H046410/1, EP/J020990/1, EP/K005278), the MRC (MR/J01107X/1), the EU-FP7 project VPH-DARE@IT (FP7-ICT-2011-9-601055), the NIHR Biomedical Research Unit (Dementia) at UCL and the National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative-BW.mn.BRC10269). Ferran Prados is funded by the National Institute for Health Research College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative) and is a Guarantors of Brain fellow. Indran Davagnanam receives support from the NIHR UCLH/UCL BRC. The Dementia Research Centre is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation. M. Jorge Cardoso receives funding from EPSRC (EP/H046410/1). The SABRE study was funded at baseline by the UK Medical Research Council, Diabetes UK and the British Heart Foundation, and at follow-up by the Wellcome Trust (WT082464), British Heart Foundation (SP/07/001/23603 and CS/13/1/30327) and Diabetes UK (13/0004774).
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: White matter hyper intensities ; Visual rating scales ; Magnetic resonance imaging ; Location ; Ageing ; BG, basal ganglia ; CI, confidence Interval ; FLAIR, fluid attenuated inversion recovery ; ICC, intraclass correlation ; IQR, interquartile range ; IT, infratentorial regions ; JC, juxtacortical ; K, Kendall's tau ; MR, magnetic resonance ; PV, periventricular ; SD, standard deviation ; WMH, white matter hyperintensities
Publicat a: Journal of Neuroradiology. Journal De Neuroradiologie, Vol. 45 (march 2018) , p. 114-122

DOI: 10.1016/j.neurad.2017.10.001
PMID: 29132940


9 p, 634.6 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació Biomèdica Sant Pau
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2018-06-18, darrera modificació el 2021-09-19



   Favorit i Compartir