Genetic variation associated with cardiovascular risk in autoimmune diseases
Perrotti, Pedro P. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Aterido, Adrià (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fernández-Nebro, Antonio (Universidad de Málaga)
Cañete, Juan D. (Hospital Clínic i Provincial de Barcelona)
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tornero, Jesús (Hospital Universitario de Guadalajara)
P. Gisbert, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Domènech, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández-Gutiérrez, Benjamín (Hospital Clínico San Carlos (Madrid))
Gomollón, Fernando (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
García-Planella, Esther (Institut d'Investigació Biomèdica Sant Pau)
Fernández, Emilia (Hospital Clínic i Provincial de Barcelona)
Sanmartí, Raimon (Hospital Clínic i Provincial de Barcelona)
Gratacós, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Martínez-Taboada, Víctor Manuel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Rodríguez-Rodríguez, Luís (Hospital Clínico San Carlos (Madrid))
Palau, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Tortosa, Raúl (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Corbeto, Mireia L. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lasanta, María L. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Marsal, Sara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Julià Cano, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca)
IMID Consortium
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Autoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. We analyzed genome-wide genotyping data from 6,485 patients from six autoimmune diseases that are associated with a high socioeconomic impact. First, for each disease, we tested the association of established CVD risk loci. Second, we analyzed the association of autoimmune disease susceptibility loci with CVD. Finally, to identify genetic patterns associated with CVD risk, we applied the crossphenotype meta-analysis approach (CPMA) on the genome-wide data. A total of 17 established CVD risk loci were significantly associated with CVD in the autoimmune patient cohorts. From these, four loci were found to have significantly different genetic effects across autoimmune diseases. Six autoimmune susceptibility loci were also found to be associated with CVD risk. Genome-wide CPMA analysis identified 10 genetic clusters strongly associated with CVD risk across all autoimmune diseases. Two of these clusters are highly enriched in pathways previously associated with autoimmune disease etiology (TNFα and IFNγ cytokine pathways). The results of this study support the presence of specific genetic variation associated with the increase of CVD risk observed in autoimmunity.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca FI-DGR 2016-00587 Ministerio de Economía y Competitividad PSE-010000-2006-6 Ministerio de Economía y Competitividad IPT-010000-2010-36
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 12 Núm. 10 (october 2017) , p. 1-17, ISSN 1932-6203

17 p, 1.9 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles