Home > Articles > Published articles > R1 and r2 relaxivities of dendrons based on a oeg-dtpa architecture : |
Date: | 2015 |
Abstract: | In magnetic resonance imaging, contrast agents are employed to enhance the signal intensity. However, current commercial contrast agents are hindered by a low relaxivity constant. Dendrimers can be employed to create higher molecular weight contrast agents which have an increased relaxivity due to a lower molecular rotation. In this study, dendrimers containing DTPA derivatives as cores and/or branching units were used to chelate gadolinium ions. Locating the gadolinium ions inside the dendrimers results in higher relaxivity constants, possibly because the paramagnetic center is closer to the rotational axis of the macromolecule. The highest gain in relaxivity was produced by decorating the dendron surface with peptide sequences, which could be explained by the presence of more second-sphere water molecules attracted by the peptides. These findings could contribute to the development of more effective contrast agents, either by placing the paramagnetic gadolinium ion in a strategic position or through functionalization of the dendron surface. |
Grants: | Ministerio de Economía y Competitividad SAF2011-30508-C02-01 Ministerio de Economía y Competitividad CTQ2012-30930 Ministerio de Economía y Competitividad SAF2011-23870 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-137 Agència de Gestió d'Ajuts Universitaris i de Recerca 2015/SGR-191 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Branching units ; Effective contrast agents ; Functionalizations ; Molecular rotations ; Paramagnetic centers ; Peptide sequences ; Rotational axis ; Signal intensities |
Published in: | Journal of Nanotechnology, Vol. 2015 (2015) , art. 848020, ISSN 1687-9511 |
9 p, 1.6 MB |