Web of Science: 1 citations, Scopus: 1 citations, Google Scholar: citations
R1 and r2 relaxivities of dendrons based on a oeg-dtpa architecture : Effect of Gd3+ placement and dendron functionalization
Fransen, Peter (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Pulido, Daniel (Parc Científic de Barcelona)
Simón Gracia, Lorena (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Albericio, Fernando (Universitat de Barcelona. Departament de Química Orgànica)
Royo, Miriam (Parc Científic de Barcelona)

Date: 2015
Abstract: In magnetic resonance imaging, contrast agents are employed to enhance the signal intensity. However, current commercial contrast agents are hindered by a low relaxivity constant. Dendrimers can be employed to create higher molecular weight contrast agents which have an increased relaxivity due to a lower molecular rotation. In this study, dendrimers containing DTPA derivatives as cores and/or branching units were used to chelate gadolinium ions. Locating the gadolinium ions inside the dendrimers results in higher relaxivity constants, possibly because the paramagnetic center is closer to the rotational axis of the macromolecule. The highest gain in relaxivity was produced by decorating the dendron surface with peptide sequences, which could be explained by the presence of more second-sphere water molecules attracted by the peptides. These findings could contribute to the development of more effective contrast agents, either by placing the paramagnetic gadolinium ion in a strategic position or through functionalization of the dendron surface.
Grants: Ministerio de Economía y Competitividad SAF2011-30508-C02-01
Ministerio de Economía y Competitividad CTQ2012-30930
Ministerio de Economía y Competitividad SAF2011-23870
Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-137
Agència de Gestió d'Ajuts Universitaris i de Recerca 2015/SGR-191
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Branching units ; Effective contrast agents ; Functionalizations ; Molecular rotations ; Paramagnetic centers ; Peptide sequences ; Rotational axis ; Signal intensities
Published in: Journal of Nanotechnology, Vol. 2015 (2015) , art. 848020, ISSN 1687-9511

DOI: 10.1155/2015/848020


9 p, 1.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles

 Record created 2019-04-09, last modified 2023-10-11



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