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R1 and r2 relaxivities of dendrons based on a oeg-dtpa architecture : Effect of Gd3+ placement and dendron functionalization
Fransen, Peter (Biomaterials and Nanomedicine. Biomedical Research Networking Center in Bioengineering)
Pulido, Daniel (Parc Científic de Barcelona. Unitat de química combinatòria)
Simón Gracia, Lorena (Biomaterials and Nanomedicine. Biomedical Research Networking Center in Bioengineering)
Candiota Silveira, Ana Paula (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Albericio, Fernando (Universitat de Barcelona. Departament de Química Orgànica)
Royo, Miriam (Parc Científic de Barcelona. Unitat de química combinatòria)

Date: 2015
Abstract: In magnetic resonance imaging, contrast agents are employed to enhance the signal intensity. However, current commercial contrast agents are hindered by a low relaxivity constant. Dendrimers can be employed to create higher molecular weight contrast agents which have an increased relaxivity due to a lower molecular rotation. In this study, dendrimers containing DTPA derivatives as cores and/or branching units were used to chelate gadolinium ions. Locating the gadolinium ions inside the dendrimers results in higher relaxivity constants, possibly because the paramagnetic center is closer to the rotational axis of the macromolecule. The highest gain in relaxivity was produced by decorating the dendron surface with peptide sequences, which could be explained by the presence of more second-sphere water molecules attracted by the peptides. These findings could contribute to the development of more effective contrast agents, either by placing the paramagnetic gadolinium ion in a strategic position or through functionalization of the dendron surface.
Note: Número d'acord de subvenció MINECO/SAF2011–30508-C02-01
Note: Número d'acord de subvenció CTQ2012-30930
Note: Número d'acord de subvenció MINECO/SAF2011-23870
Note: Número d'acord de subvenció AGAUR/2014/SGR-137
Note: Número d'acord de subvenció AGAUR/2015/SGR-191
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Branching units ; Effective contrast agents ; Functionalizations ; Molecular rotations ; Paramagnetic centers ; Peptide sequences ; Rotational axis ; Signal intensities
Published in: Journal of Nanotechnology, Vol. 2015 (2015) , art. 848020, ISSN 1687-9511

DOI: 10.1155/2015/848020


9 p, 1.6 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-04-09, last modified 2019-06-04



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