Long-term moderate treadmill exercise promotes stress-coping strategies in Male and female rats
F. Lalanza, Jaume (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Sanchez-Roige, Sandra (University of Sussex. School of Psychology)
Cigarroa, Igor (Universidad Santo Tomás)
Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Fuentes, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Capdevila Ortís, Lluís (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació)
Escorihuela, Rosa M. (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2015
Abstract:	Recent evidence has revealed the impact of exercise in alleviating anxiety and mood disorders; however, the exercise protocol that exerts such benefit is far from known. The current study was aimed to assess the effects of long-term moderate exercise on behavioural coping strategies (active vs. passive) and Hypothalamic-Pituitary-Adrenal response in rats. Sprague-Dawley male and female rats were exposed to 32-weeks of treadmill exercise and then tested for two-way active avoidance learning (shuttle-box). Two groups were used as controls: a non-handled sedentary group, receiving no manipulation, and a control group exposed to a stationary treadmill. Female rats displayed shorter escape responses and higher number of avoidance responses, reaching criterion for performance earlier than male rats. In both sexes, exercise shortened escape latencies, increased the total number of avoidances and diminished the number of trials needed to reach criterion for performance. Those effects were greater during acquisition in female rats, but remained over the shuttle-box sessions in treadmill trained male rats. In females, exercise did not change ACTH and corticosterone levels after shuttle-box acquisition. Collectively, treadmill exercise improved active coping strategies in a sex-dependent manner. In a broader context, moderate exercise could serve as a therapeutic intervention for anxiety and mood disorders.
Grants:	Instituto de Salud Carlos III RD12-0028-0014 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1020 Ministerio de Economía y Competitividad PSI2011-29807-C02-01 Ministerio de Economía y Competitividad SAF2011-28313 Agència de Gestió d'Ajuts Universitaris i de Recerca 2011/FI-DGR
Note:	This study has been supported by Spanish grants from Ministerio de Economía y Competitividad to LC (PSI2011-29807-C02-01) and AA (SAF2011-28313); and from Instituto de Salud Carlos III (RD12/0028/0014, Redes Temáticas de Investigación Cooperativa en Salud, Ministerio de Sanidad y Consumo), and Generalitat de Catalunya (SGR2014-1020) to AA. JFL was supported by a pre-doctoral fellowship from the Generalitat de Catalunya (FI-DGR 2011). IC was supported by a pre-doctoral fellowship from Universidad Santo Tomás, Chile and a fellowship from CONYCYT/BECA CHILE/PAI 72150035. SF was a recipient of a PTA-MICINN fellowship (PTA 2010-3472-I). We would like to thank Juan Ramón Garcia Milla, Rafaela Gascón Palomar, Carlos Baldellou Estrada, Maria del Mar López González and all Servei d'Estabulari staff (UAB) for their help with animal care.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adaptation, Psychological ; Adrenocorticotropic Hormone ; Animals ; Anxiety ; Avoidance Learning ; Corticosterone ; Exercise Test ; Female ; Hypothalamo-Hypophyseal System ; Hypothalamus ; Male ; Physical Conditioning, Animal ; Pituitary-Adrenal System ; Rats ; Rats, Sprague-Dawley ; Stress, Physiological
Published in:	Scientific reports, Vol. 5 (May 2015) , art. 16166, ISSN 2045-2322

DOI: 10.1038/srep16166
PMID: 26538081

11 p, 743.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Grupo de investigación Laboratorio Humano (Grupo LabHumàUAB)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles