The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
Bâlteanu, Valentin Adrian (Institute of Life Sciences (Cluj-Napoca, Romania))
Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica)
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica)
Egerszegi, István (Szent István University)
Anton, I. (Nemzeti Agrárkutatási és Innovációs Központ)
Beja Pereira, Albano (Universidade do Porto. Centro de Investigação em Biodiversidade e Recursos Genéticos)
Zsolnai, Attila (Nemzeti Agrárkutatási és Innovációs Központ)

Data:	2019
Resum:	The Mangalitza pig breed has suffered strong population reductions due to competition with more productive cosmopolitan breeds. In the current work, we aimed to investigate the effects of this sustained demographic recession on the genomic diversity of Mangalitza pigs. By using the Porcine Single Nucleotid Polymorphism BeadChip, we have characterized the genome-wide diversity of 350 individuals including 45 Red Mangalitza (number of samples; n=20 from Hungary and n=25 from Romania), 37 Blond Mangalitza, 26 Swallow-belly Mangalitza, 48 Blond Mangalitza × Duroc crossbreds, 5 Bazna swine, 143 pigs from the Hampshire, Duroc, Landrace, Large White and Pietrain breeds and 46 wild boars from Romania (n=18) and Hungary (n=28). Performance of a multidimensional scaling plot showed that Landrace, Large White and Pietrain pigs clustered independently from Mangalitza pigs and Romanian and Hungarian wild boars. The number and total length of ROH (runs of homozygosity), as well as FROH coefficients (proportion of the autosomal genome covered ROH) did not show major differences between Mangalitza pigs and other wild and domestic pig populations. However, Romanian and Hungarian Red Mangalitza pigs displayed an increased frequency of very long ROH (>30 Mb) when compared with other porcine breeds. These results indicate that Red Mangalitza pigs underwent recent and strong inbreeding probably as a consequence of severe reductions in census size.
Ajuts:	Ministerio de Economía y Competitividad AGL2013-48742-C2-1-R
Nota:	Altres ajuts: The authors also acknowledge the support of the Spanish Ministry of Economy and Competitivity for the Center of Excellence Severo Ochoa 2016-2019 (SEV-2015-0533) grant awarded to the Centre for Research in Agricultural Genomics (CRAG). Tainã Figueiredo Cardoso was funded with a fellowship from the CAPES Foundation-Coordination of Improvement of Higher Education, Ministry of Education of the Federal Government of Brazil. Thanks also to the CERCA Programme of the Generalitat de Catalunya.
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Polymorphisms ; Population ; Structure ; Admixture ; Homozygosity
Publicat a:	Animal, Vol. 13, issue 11 (Nov. 2019) , p. 2440-2446, ISSN 1751-732X

DOI: 10.1017/S1751731119000582
PMID: 30947762

Postprint 39 p, 2.7 MB

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