Silica coated iron/iron oxide nanoparticles as a nano-platform for T2 weighted magnetic resonance imaging
Mathieu, Paul (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination)
Coppel, Yannick (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination)
Respaud, Marc (Institut National des Sciences Appliquées. Laboratoire de Physique et Chimie des Nano-objets)
Nguyen, Quyen T. (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination)
Boutry, Sébastien (University of Mons. Department of General, Organic and Biomedical Chemistry)
Laurent, Sophie (University of Mons. Department of General, Organic and Biomedical Chemistry)
Stanicki, Dimitri (University of Mons. Department of General, Organic and Biomedical Chemistry)
Henoumont, Céline (University of Mons. Department of General, Organic and Biomedical Chemistry)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Montpeyó Garcia-Moreno, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Amiens, Catherine (Centre national de la recherche scientifique (França). Laboratoire de Chimie de Coordination)

Data:	2019
Resum:	The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron-iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. Here we report the synthesis of 10 nm large Fe@FeOx nanoparticles, their coating with a 11 nm thick layer of dense silica and functionalization by 5 kDa PEG chains to improve their biocompatibility. The nanomaterials obtained have been characterized by a set of complementary techniques such as infra-red and nuclear magnetic resonance spectroscopies, transmission electron microscopy, dynamic light scattering and zetametry, and magnetometry. They display hydrodynamic diameters in the 100 nm range, zetapotential values around -30 mV, and magnetization values higher than the reference contrast agent RESOVIST®. They display no cytotoxicity against 1BR3G and HCT116 cell lines and no hemolytic activity against human red blood cells. Their nuclear magnetic relaxation dispersion (NMRD) profiles are typical for nanomaterials of this size and magnetization. They display high r2 relaxivity values and low r1 leading to enhanced r2/r1 ratios in comparison with RESOVIST®. All these data make them promising contrast agents to detect early stage tumors.
Ajuts:	Ministerio de Ciencia e Innovación RTI2018-098027-B-C22
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Nanomaterials ; Nanochemistry ; Surface functionalization ; MRI ; Toxicity
Publicat a:	Molecules, Vol. 24, issue 24 (Dec. 2019) , art. 4629, ISSN 1420-3049

DOI: 10.3390/molecules24244629
PMID: 31861222

20 p, 4.8 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Biotecnologia i de Biomedicina (IBB)
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