Intestinal mucosal mast cells : key modulators of barrier function and homeostasis
Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron)
Paracuellos, Irene (Hospital Universitari Vall d'Hebron)
González Castro, Ana Maria (Hospital Universitari Vall d'Hebron)
Rodríguez-Urrutia, Amanda (Universitat Autònoma de Barcelona)
Rodríguez-Lagunas, María J. (Universitat de Barcelona)
Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron)
Santos, Javier (Hospital Universitari Vall d'Hebron)
Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)

Data:	2019
Resum:	The gastrointestinal tract harbours the largest opulation of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides. Mast cells react to external and internal stimuli thanks to the variety of receptors they express, and carry out effector and regulatory tasks by means of the mediators of different natures they produce. Mast cells are fundamental elements of the intestinal barrier as they regulate epithelial function and integrity, modulate both innate and adaptive mucosal immunity, and maintain neuro-immune interactions, which are key to functioning of the gut. Disruption of the intestinal barrier is associated with increased passage of luminal antigens into the mucosa, which further facilitates mucosal mast cell activation, inflammatory responses, and altered mast cell-enteric nerve interaction. Despite intensive research showing gut dysfunction to be associated with increased intestinal permeability and mucosal mast cell activation, the specific mechanisms linking mast cell activity with altered intestinal barrier in human disease remain unclear. This review describes the role played by mast cells in control of the intestinal mucosal barrier and their contribution to digestive diseases.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Intestinal barrier function ; Mucosal mast cells
Publicat a:	Cells, Vol. 8 (2019) , p. 1-24, ISSN 2073-4409

DOI: 10.3390/cells8020135
PMID: 30744042

24 p, 1.4 MB

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