Web of Science: 26 cites, Scopus: 23 cites, Google Scholar: cites,
Chromosomics : bridging the gap between genomes and chromosomes
E. Deakin, Janine (University of Canberra. Institute for Applied Ecology)
Potter, Sally (Australian National University)
O'Neill, Rachel (University of Connecticut. Institute for Systems Genomics and Department of Molecular and Cell Biology)
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
B. Ciof, Marcelo (Universidade Federal de São Carlos)
D.B. Eldridge, Mark (Australian Museum Research Institute)
Fukui, Kichi (Osaka University. Graduate School of Pharmaceutical Sciences)
Marshall Graves, Jennifer A. (University of Canberra. Institute for Applied Ecology)
Griffin, Darren (University of Kent. School of Biosciences)
Grutzner, Frank (The University of Adelaide. School of Biological Sciences)
Kratochvíl, Lukáš (Charles University. Department of Ecology)
Miura, Ikuo (Hiroshima University. Amphibian Research Center)
Rovatsos, Michail (The University of Adelaide. School of Biological Sciences)
Srikulnath, Kornsorn (Kasetsart University. Department of Genetics, Faculty of Science)
Wapstra, Erik (University of Tasmania. School of Natural Sciences)
Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"

Data: 2019
Resum: The recent advances in DNA sequencing technology are enabling a rapid increase in the number of genomes being sequenced. However, many fundamental questions in genome biology remain unanswered, because sequence data alone is unable to provide insight into how the genome is organised into chromosomes, the position and interaction of those chromosomes in the cell, and how chromosomes and their interactions with each other change in response to environmental stimuli or over time. The intimate relationship between DNA sequence and chromosome structure and function highlights the need to integrate genomic and cytogenetic data to more comprehensively understand the role genome architecture plays in genome plasticity. We propose adoption of the term 'chromosomics' as an approach encompassing genome sequencing, cytogenetics and cell biology, and present examples of where chromosomics has already led to novel discoveries, such as the sex-determining gene in eutherian mammals. More importantly, we look to the future and the questions that could be answered as we enter into the chromosomics revolution, such as the role of chromosome rearrangements in speciation and the role more rapidly evolving regions of the genome, like centromeres, play in genome plasticity. However, for chromosomics to reach its full potential, we need to address several challenges, particularly the training of a new generation of cytogeneticists, and the commitment to a closer union among the research areas of genomics, cytogenetics, cell biology and bioinformatics. Overcoming these challenges will lead to ground-breaking discoveries in understanding genome evolution and function.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Cytogenetics ; Sex chromosomes ; Chromosome rearrangements ; Genome plasticity ; Centromere ; Genome biology ; Evolution
Publicat a: Genes, Vol. 10 (2019) , p. 1-17, ISSN 2073-4425

DOI: 10.3390/genes10080627
PMID: 31434289


17 p, 933.8 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Biotecnologia i de Biomedicina (IBB)
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 Registre creat el 2020-01-22, darrera modificació el 2021-08-01



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