Web of Science: 45 cites, Scopus: 49 cites, Google Scholar: cites,
A systems-oriented analysis of the grapevine R2R3-MYB transcription factor family uncovers new insights into the regulation of stilbene accumulation
Wong, Darren Chern Jan (University of British Columbia. Wine Research Centre)
Schlechter, Rudolf (Eidgenössische Technische Hochschule Zurich. Department of Biology)
Vannozzi, Alessandro (Università degli studi di Padova. Dipartimento di Agronomia Animali Alimenti Risorse Naturali e Ambiente)
Höll, Janine (Universität Heidelberg. Centre for Organismal Studies Heidelberg)
Hmmam, Ibrahim (Università degli studi di Padova. Dipartimento di Agronomia Animali Alimenti Risorse Naturali e Ambiente)
Bogs, Jochen (Dienstleistungszentrum Laendlicher Raum Rheinpfalz)
Tornielli, Giovanni Battista (Università di Verona. Dipartimento di Biotecnologie)
Castellarin, Simone Diego (University of British Columbia. Wine Research Centre)
Matus, José Tomás (Centre de Recerca en Agrigenòmica)

Data: 2016
Resum: R2R3-MYB transcription factors (TFs) belong to a large and functionally diverse protein superfamily in plants. In this study, we explore the evolution and function of this family in grapevine (Vitis vinifera L. ), a high-value fruit crop. We identified and manually curated 134 genes using RNA-Seq data, and named them systematically according to the Super-Nomenclature Committee. We identified novel genes, splicing variants and grapevine/woody-specific duplicated subgroups, suggesting possible neo- and sub-functionalization events. Regulatory network analysis ascribed biological functions to uncharacterized genes and validated those of known genes (e. g. secondary cell wall biogenesis and flavonoid biosynthesis). A comprehensive analysis of different MYB binding motifs in the promoters of co-expressed genes predicted grape R2R3-MYB binding preferences and supported evidence for putative downstream targets. Enrichment of cis-regulatory motifs for diverse TFs reinforced the notion of transcriptional coordination and interaction between MYBs and other regulators. Analysis of the network of Subgroup 2 showed that the resveratrol-related VviMYB14 and VviMYB15 share common co-expressed STILBENE SYNTHASE genes with the uncharacterized VviMYB13. These regulators have distinct expression patterns within organs and in response to biotic and abiotic stresses, suggesting a pivotal role of VviMYB13 in regulating stilbene accumulation in vegetative tissues and under biotic stress conditions.
Drets: Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and pages. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Wine ; Cell wall ; Ripening ; Radiation ; Stress
Publicat a: DNA research, Vol. 23, issue 5 (Oct. 2016) , p. 451-466, ISSN 1756-1663

DOI: 10.1093/dnares/dsw028
PMID: 27407139


16 p, 1.5 MB

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