Metabolic adaptation in the human gut microbiota during pregnancy and the first year of life
Gosalbes, María José (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Compte, Joan (Hospital Universitari Vall d'Hebron)
Moriano-Gutierrez, Silvia (Pacific Biosciences Research Center. School of Ocean and Earth Science and Technology. University of Hawaii at Mānoa)
Vallès, Yvonne (Department of Biological and Chemical Sciences. The University of the West Indies)
Jiménez-Hernández, Núria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Pons Tamarit, Xavier (Universitat de València. Institut de Biologia Integrativa de Sistemes)
Artacho, Alejandro (Universitat de València. Institut de Biologia Integrativa de Sistemes)
Francino, M. Pilar (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Background: The relationship between the gut microbiome and the human host is dynamic and we may expect adjustments in microbiome function if host physiology changes. Metatranscriptomic approaches should be key in unraveling how such adjustments occur. Methods: We employ metatranscriptomic sequencing analyses to study gene expression in the gut microbiota of infants through their first year of life, and of their mothers days before delivery and one year afterwards. Findings: In infants, hallmarks of aerobic metabolism disappear from the microbial metatranscriptome as development proceeds, while the expression of functions related to carbohydrate transport and metabolism increases and diversifies, approaching that observed in non-pregnant women. Butyrate synthesis enzymes are overexpressed at three months of age, even though most butyrate-producing organisms are still rare. In late pregnancy, the microbiota readjusts the expression of carbohydrate-related functions in a manner consistent with a high availability of glucose. Interpretation: Our findings suggest that butyrate production may be ensured in the gut of young infants before the typical butyrate synthesizers of the adult gut become abundant. The late pregnancy gut microbiota may be able to access the high levels of blood glucose characteristic of this period. Moreover, late pregnancy gut bacteria may reach stationary phase, which may affect their likelihood of translocating across the intestinal epithelium. Funds: This work was supported by grants CSD2009-00006 (CONSOLIDER Program) and SAF2009-13032-C02-02 from MICINN (Ministry of Science and Innovation, Spain), and by grant SAF2012-31187 from MINECO (Ministry of Economics and Competitiveness, Spain).
Ajuts:	Ministerio de Ciencia e Innovación SAF2009-13032-C02-02 Ministerio de Economía y Competitividad SAF2012-31187
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	EBioMedicine, Vol. 39 (january 2019) , p. 497-509, ISSN 2352-3964

DOI: 10.1016/j.ebiom.2018.10.071
PMID: 30415891

13 p, 3.6 MB

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