Dual T1/ T2 Nanoscale Coordination Polymers as Novel Contrast Agents for MRI : A Preclinical Study for Brain Tumor
Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia)
Arias-Ramos, Nuria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Frias Botella, Carolina (Institut Català de Nanociència i Nanotecnologia)
Candiota Silveira, Ana Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Arús i Caraltó, Carles (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)

Data:	2018
Resum:	In the last years, extensive attention has been paid on designing and developing functional imaging contrast agents for providing accurate noninvasive evaluation of pathology in vivo. However, the issue of false-positives or ambiguous imaging and the lack of a robust strategy for simultaneous dual-mode imaging remain to be fully addressed. One effective strategy for improving it is to rationally design magnetic resonance imaging (MRI) contrast agents (CAs) with intrinsic T/T dual-mode imaging features. In this work, the development and characterization of one-pot synthesized nanostructured coordination polymers (NCPs) which exhibit dual mode T/T MRI contrast behavior is described. The resulting material comprises the combination of different paramagnetic ions (Fe, Gd, Mn) with selected organic ligands able to induce the polymerization process and nanostructure stabilization. Among them, the Fe-based NCPs showed the best features in terms of colloidal stability, low toxicity, and dual T/T MRI contrast performance overcoming the main drawbacks of reported CAs. The dual-mode CA capability was evaluated by different means: in vitro phantoms, ex vivo and in vivo MRI, using a preclinical model of murine glioblastoma. Interestingly, the in vivo MRI of Fe-NCPs show T and T high contrast potential, allowing simultaneous recording of positive and negative contrast images in a very short period of time while being safer for the mouse. Moreover, the biodistribution assays reveals the persistence of the nanoparticles in the tumor and subsequent gradual clearance denoting their biodegradability. After a comparative study with commercial CAs, the results suggest these nanoplatforms as promising candidates for the development of dual-mode MRI CAs with clear advantages.
Ajuts:	Ministerio de Economía y Competitividad MAT2015-70615-R Ministerio de Economía y Competitividad BIO2016-78057-R Ministerio de Economía y Competitividad SEV-2013-0295
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Imaging agents ; Metals ; Nanoparticles ; Magnetic resonance imaging ; Toxicity
Publicat a:	ACS applied materials & interfaces, Vol. 10, Issue 45 (November 2018) , p. 38819-38832, ISSN 1944-8252

DOI: 10.1021/acsami.8b15594
PMID: 30351897

Postprint 51 p, 1.4 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Biotecnologia i de Biomedicina (IBB)
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Institut Català de Nanociència i Nanotecnologia (ICN2)
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