Autophagy modulators : mechanistic aspects and drug delivery systems
Tavakol, Shima (Iran University of Medical Sciences. Cellular and Molecular Research Center)
Ashrafizadeh, Milad (University of Tabriz. Department of basic science)
Deng, Shuo (National University of Singapore. Department of Physiology)
Azarian, Maryam (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Abdoli, Asghar (Pasteur Institute of Iran. Department of Hepatitis and AIDS)
Motavaf, Mahsa (Tarbiat Modares University. Department of Molecular Genetics)
Poormoghadam, Delaram (Islamic Azad University. Department of Medical Nanotechnology)
Khanbabaei, Hashem (Ahvaz Jundishapur University of Medical Sciences. Medical Physics Departmen)
Ghasemipour Afshar, Elham (Kerman University of Medical Sciences. Neuroscience Research Center)
Mandegary, Ali (Kerman University of Medical Sciences. Neuroscience Research Center)
Pardakhty, Abbas (Kerman University of Medical Sciences. Neuroscience Research Center)
Yap, Celestial T. (National University of Singapore. Department of Physiology)
Mohammadinejad, Reza (Kerman University of Medical Sciences. Pharmaceutics Research Center)
Prem Kumar, Alan (Cancer Science Institute of Singapore)
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Data:	2019
Resum:	Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. This knowledge will help scientists find approaches to manipulate tumor and pathologic cells in order to enhance cellular sensitivity to therapeutics and treat them. Although some conventional therapeutics suffer from poor solubility, bioavailability and controlled release mechanisms, it appears that novel nanoplatforms overcome these obstacles and have led to the design of a theranostic-controlled drug release system with high solubility and active targeting and stimuli-responsive potentials. In this review, we discuss autophagy modulators-related signaling pathways and some of the drug delivery strategies that have been applied to the field of therapeutic application of autophagy modulators. Moreover, we describe how therapeutics will target various steps of the autophagic machinery. Furthermore, nano drug delivery platforms for autophagy targeting and co-delivery of autophagy modulators with chemotherapeutics/siRNA, are also discussed.
Nota:	Funding: this work was supported by a grant from NMRC-CIRG to CTY. APK was supported by grants from National Medical Research Council of Singapore, NCIS Yong Siew Yoon Research Grant through donations from the Yong Loo Lin Trust and by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centers of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore. R.M. acknowledges financial supports of Kerman University of Medical Sciences.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	AMPK ; Nanocarriers ; Autophagy ; Cancer ; Combination therapy ; Mtor ; Sirna
Publicat a:	Biomolecules, Vol. 9, issue 10 (Sep. 2019) , art. 530, ISSN 2218-273X

DOI: 10.3390/biom9100530
PMID: 31557936

41 p, 2.4 MB

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