Management of Heart Failure with Reduced Ejection Fraction after ESC 2016 Heart Failure Guidelines : The Linx Registry
De Frutos, Fernando (Hospital Universitari de Bellvitge)
Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Ortega-Paz, Luis (Hospital Clínic i Provincial de Barcelona)
Buera Surribas, Irene (Hospital de Viladecans)
Darnés, Sara (Hospital de Figueres)
Farré, Núria (Institut Hospital del Mar d'Investigacions Mèdiques)
Perez, Bernardo (Hospital General de Granollers)
Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bascompte, Ramón (Hospital Arnau de Vilanova (Lleida, Catalunya))
Pérez-Rodón, Jordi (Hospital Universitari Vall d'Hebron)
Aparicio, Xavier (Hospital de Mataró. Consorci Sanitari del Maresme)
Sutil-Vega, Mario (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Soto, Adriana (Hospital de Martorell)
Faraudo, Mercedes (Hospital de Sant Joan Despí Moisès Broggi)
Cainzos-Achirica, Miguel (Hospital Universitari de Bellvitge)
Manito, Nicolás (Hospital Universitari de Bellvitge)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	In May 2016, a new version of the European Society of Cardiology (ESC) Guidelines for the management of heart failure (HF) was released. The aim of this study was to describe the management of HF with reduced ejection fraction after the publication of ESC Guidelines. The Linx registry is a multicentre, observational, cross-sectional study from 14 Catalan hospitals that enrolled 1056 patients with HF and reduced left ventricular ejection fraction (≤40%) from 1 February to 30 April 2017 in outpatient cardiology clinics. Results were compared between hospitals according to their level of complexity in our own registry and compared with previously published registries similar to ours. Sacubitril/valsartan was prescribed to 23. 9% of patients in our population, as a consequence, use of angiotensin-converting enzyme inhibitor and angiotensin receptor blockers in monotherapy decreased to 48. 1% and 16. 9%, respectively, and prescription of beta-blockers (91. 8%), mineralocorticoid receptor antagonists (72. 7%), and ivabradine (21. 4%) remained similar to previous registries. Target doses of beta-blockers (25. 4%), angiotensin-converting enzyme inhibitors (24. 9%), angiotensin receptor blockers (7. 7%), sacubitril/valsartan (8. 1%), and mineralocorticoid receptor antagonists (19. 7%) were accomplished in a low proportion of patients. Our results also suggest that prescription and up-titration of class I HF drugs were greater in hospitals with higher level of complexity. The Linx registry shows an appropriate adherence to pharmacological recommendations from ESC HF Guidelines despite a low proportion of patients reached target doses. Almost one-quarter of patients were under treatment with sacubitril/valsartan a few months after ESC HF Guidelines recommendations.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chronic heart failure ; Guidelines ; Heart failure ; Management ; Sacubitril/valsartan
Published in:	ESC Heart Failure, Vol. 7 (january 2020) , p. 25-35, ISSN 2055-5822

DOI: 10.1002/ehf2.12567
PMID: 31916413

11 p, 2.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles