Ethyl Pyruvate Induces Tolerogenic Dendritic Cells
Djedovic, Neda (University of Belgrade. Department of Immunology)
Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Jevtić, Bojan (University of Belgrade. Department of Immunology)
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Saksida, Tamara (University of Belgrade. Department of Immunology)
Martínez-Cáceres, Eva M. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Miljković, Ðorđe (University of Belgrade. Department of Immunology)

Date:	2019
Abstract:	Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and other autoimmune diseases. Ethyl pyruvate (EP) is a redox analog of dimethyl fumarate (Tecfidera), a drug for multiple sclerosis treatment. We have recently shown that EP ameliorates experimental autoimmune encephalomyelitis, a multiple sclerosis murine model. Here, we expanded our study to its tolerogenic effects on DC. Phenotypic analysis has shown that DC obtained from mice or humans reduce expression of molecules required for T cell activation such as CD86, CD83, and HLA-DR under the influence of EP, while CD11c expression and viability of DC are not affected. Furthermore, EP-treated DC restrain proliferation and modulate cytokine production of allogeneic lymphocytes. These results demonstrate that EP has the ability to direct DC toward tolDC.
Grants:	Instituto de Salud Carlos III PI14-01175 Instituto de Salud Carlos III PI17/01521
Note:	Altres ajuts: Cost Action BM1305
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Dendritic cells ; Ethyl pyruvate ; Autoimmunity ; Tolerogenicity ; Immune-regulation
Published in:	Frontiers in immunology, Vol. 10 (February 2019) , art. 157, ISSN 1664-3224

DOI: 10.3389/fimmu.2019.00157
PMID: 30792716

11 p, 2.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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