Interhemispheric and Intrahemispheric Connectivity From the Left Pars Opercularis Within the Language Network Is Modulated by Transcranial Stimulation in Healthy Subjects
Yoo, Woo-Kyoung (Department of Physical Medicine and Rehabilitation, Hallym University Sacred Heart Hospital)
Vernet, Marine (ImpAct Team, Lyon Neuroscience Research Center (CRNL), CNRS UMR5292, INSERM, U1028, University Lyon 1)
Hoon Kim, Jeong (Department of Biomedical Engineering, Hanyang University)
Brem, Anna-Katharine (Department of Neuropsychology, Memory Clinic Zentralschweiz, Lucerne Psychiatry)
Bashir, Shahid (Department of Neurophysiology, Neuroscience Center, King Fahad Specialist Hospital)
Ifert-Miller, Fritz (Department of Neurology, Harvard Medical School)
Im, Chang-Hwan (Department of Biomedical Engineering, Hanyang University)
Eldaief, Mark (Department of Neurology, Harvard Medical School)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Neural activity related to language can be modulated within widespread networks following learning or in response to disruption-including the experimental application of noninvasive brain stimulation. However, the spatiotemporal characteristics of such modulation remain insufficiently explored. The present study combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to explore the modulation of activity across the language network following continuous theta-burst stimulation (cTBS) of the left pars opercularis. In 10 healthy subjects (21 ± 2 years old, four females), neuronavigated cTBS was delivered over the left pars opercularis of the frontal operculum (part of the traditional Broca's area) at 80% of active motor threshold (AMT) stimulation intensity. Real cTBS and sham cTBS were performed in two different visits separated by at least 48 h. Before, immediately, and 10 min after cTBS, 30 single pulses of TMS were delivered to the left pars opercularis at 80% of the resting motor threshold (RMT), whereas EEG was simultaneously recorded. We examined the cTBS-induced modulation of phase locking values (PLVs) between the TMS-evoked potentials (TEPs) recorded over the pars opercularis and those recorded over its right-hemispheric homolog area, the left supramarginal area, and the left superior temporal area in different EEG frequency bands and different time windows following cTBS. cTBS to the left pars opercularis induced within the gamma band: (1) a significant increase in TEP phase synchronization between the left and right pars opercularis at an early time window (250-350 ms) following cTBS; and (2) significantly increased PLV with the left supramarginal area and the left superior temporal area at a later time window (600-700 ms). In the theta and delta band, cTBS to the left pars opercularis induced significantly increased phase synchronization of TEPs between the left pars opercularis and the posterior left hemispheric language areas at a late time window. In sham condition, there was a significant decrease in TEP phase synchronization of the high beta band between left pars opercularis and left superior temporal area at 200-300 ms. These results contribute to characterize the dynamics of the language network and may have implications in the development of noninvasive stimulation protocols to promote the language rehabilitation in aphasia patients.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Noninvasive brain stimulation ; TMS-evoked potentials ; Gamma band ; Phase synchronization ; Continuous theta-burst stimulation
Publicat a:	Frontiers in human neuroscience, Vol. 14 (march 2020) , ISSN 1662-5161

DOI: 10.3389/fnhum.2020.00063
PMID: 32256324

9 p, 1.3 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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