(Health Research Institute of Santiago de Compostela (IDIS). Clinical Neurosciences Research Laboratory)
(Health Research Institute of Santiago de Compostela (IDIS). Clinical Neurosciences Research Laboratory)
(Health Research Institute of Santiago de Compostela (IDIS). Clinical Neurosciences Research Laboratory)
(Health Research Institute of Santiago de Compostela (IDIS). Clinical Neurosciences Research Laboratory)
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
| Fecha: |
2019 |
| Resumen: |
The main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62. 1%; mean age, 68. 2 ± 11. 4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] ≤ 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 ± 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1α were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1α serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0. 01). High serum levels at day 7 of VEGF (OR, 19. 3), Ang-1 (OR, 14. 7), G-CSF (OR, 9. 6), and SDF-1α (OR, 28. 5) were independently associated with good outcome at 12 months (all p < 0. 0001). On the other hand, serum levels of VEGF (B, − 21. 4), G-CSF (B, − 14. 0), Ang-1 (B, − 13. 3), and SDF-1α (B, − 44. 6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0. 01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1α at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up. |
| Nota: |
Altres ajuts: This project was partially supported by grants from Xunta de Galicia (Consellería Educación: GRC2014/027 and IN607A2018/3), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS (RD16/0019), and by the European Union FEDER program. |
| Nota: |
Número d'acord de subvenció MINECO/SAF2014-56336-R |
| Nota: |
Número d'acord de subvenció MINECO/RTI2018-102165-B-I00 |
| Nota: |
Número d'acord de subvenció MINECO/SAF2017-84267-R |
| Nota: |
Número d'acord de subvenció ISCIII/PI13-00292 |
| Nota: |
Número d'acord de subvenció ISCIII/PI14-01879 |
| Nota: |
Número d'acord de subvenció ISCIII/PI17-01103 |
| Nota: |
Número d'acord de subvenció ISCIII/CP12-03121 |
| Nota: |
Número d'acord de subvenció ISCIII/CPII17-00027 |
| Nota: |
Número d'acord de subvenció ISCIII/CP14-00154 |
| Nota: |
Número d'acord de subvenció ISCIII/CPII19-00020 |
| Lengua: |
Anglès |
| Documento: |
article ; recerca ; publishedVersion |
| Materia: |
Growth factors ;
Infarct volume ;
Ischemic stroke ;
Prognosis |
| Publicado en: |
Translational Stroke Research, Vol. 11 (november 2019) , p. 653-663, ISSN 1868-601X |
visitante ::
identificación
(Health Research Institute of Santiago de Compostela (IDIS). Clinical Neurosciences Research Laboratory)
