Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management
Ramiro, Laura (Hospital Universitari Vall d'Hebron)
Simats Oriol, Alba
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2018
Resum:	Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide. Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to diagnose stroke is still a major concern. In addition, therapeutic approaches to combat ischemic stroke are still scarce, since the only approved therapies are directed toward restoring blood flow to the affected brain area. However, due to the reduced time window during which these therapies are effective, few patients benefit from them; therefore, alternative treatments are urgently needed to reduce stroke brain damage in order to improve patients' outcome. The inflammatory response triggered after the ischemic event plays an important role in the progression of stroke; consequently, the study of inflammatory molecules in the acute phase of stroke has attracted increasing interest in recent decades. Here, we provide an overview of the inflammatory processes occurring during ischemic stroke, as well as the potential for these inflammatory molecules to become stroke biomarkers and the possibility that these candidates will become interesting neuroprotective therapeutic targets to be blocked or stimulated in order to modulate inflammation after stroke.
Ajuts:	Instituto de Salud Carlos III FIS/PI15-00354 Instituto de Salud Carlos III IFI17-00012 Agència de Gestió d'Ajuts Universitaris i de Recerca 2015FI_B00952
Nota:	Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Neurovascular Research Laboratory acknowledges funding for this project through a grant from Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III (cofinanced by the European Regional Development Fund, FEDER). The Neurovascular Research Laboratory also takes part in the Spanish stroke research network INVICTUS+ (RD16/0019). L Ramiro is supported by a predoctoral fellowship grant from the Instituto de Salud Carlos III, and A Simats is supported by a predoctoral fellowship grant from AGAUR.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biomarkers ; Cerebrovascular disease ; Inflammation ; Neuroprotection ; Stroke ; Therapeutic targets
Publicat a:	Therapeutic Advances in Neurological Disorders, Vol. 11 (august 2018) , ISSN 1756-2864

DOI: 10.1177/1756286418789340
PMID: 30093920

24 p, 770.3 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats