Endothelial damage, inflammation and immunity in chronic kidney disease
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Torramade-Moix, S. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Pascual, G. (Arrels Centre Dental)
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Moreno-Castaño, Ana Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Martínez-Sánchez, Julia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Vera, M. (Hospital Clínic i Provincial de Barcelona)
Cases, A. (Hospital Clínic i Provincial de Barcelona)
Escolar, Ginès (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Chronic kidney disease (CKD) patients have an accelerated atherosclerosis, increased risk of thrombotic-ischemic complications, and excessive mortality rates when compared with the general population. There is also evidence of an endothelial damage in which the proinflammatory state, the enhanced oxidative stress, or the accumulation of toxins due to their reduced renal clearance in uremia play a role. Further, there is evidence that uremic endothelial cells are both involved in and victims of the activation of the innate immunity. Uremic endothelial cells produce danger associated molecular patterns (DAMPS), which by binding to specific pattern recognition receptors expressed in multiple cells, including endothelial cells, induce the expression of adhesion molecules, the production of proinflammatory cytokines and an enhanced production of reactive oxygen species in endothelial cells, which constitute a link between immunity and inflammation. The connection between endothelial damage, inflammation and defective immunity in uremia will be reviewed here.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-675 Instituto de Salud Carlos III PIE15-00027 Instituto de Salud Carlos III PI19-00888
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió publicada
Subject:	Chronic kidney disease (CKD) ; Uremia ; Endothelial cells ; Endothelial damage ; Inflammation ; Innate immunity ; Oxidative stress
Published in:	Toxins, Vol. 12 Núm. 6 (june 2020) , p. 361, ISSN 2072-6651

DOI: 10.3390/toxins12060361
PMID: 32492843

21 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
Articles > Published articles