Donkey genomes provide new insights into domestication and selection for coat color
Wang, Changfa (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding)
Li, Haijing (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine)
Guo, Yu (BGI-Shenzhen)
Huang, Jinming (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Sun, Yan (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Min, Jiumeng (BGI-Shenzhen)
Wang, Jinpeng (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Fang, Xiaodong (BGI-Shenzhen)
Zhao, Zicheng (City University of Hong Kong. Department of Computer Science)
Wang, Shuai (City University of Hong Kong. Department of Computer Science)
Zhang, Yanlin (City University of Hong Kong. Department of Computer Science)
Liu, Qingfeng (BGI-Shenzhen)
Jiang, Qiang (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Wang, Xiuge (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Guo, Yijun (BGI-Shenzhen)
Yang, Chunhong (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Wang, Yinchao (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine)
Tian, Fang (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine)
Zhuang, Guilong (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Fan, Yanna (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Gao, Qican (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Li, Yuhua (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding)
Ju, Zhihua (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Li, Jianbin (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Li, Rongling (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Hou, Minghai (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Yang, Guiwen (Shandong Normal University. College of Life Science)
Liu, Guiqin (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding)
Liu, Wenqiang (Liaocheng University Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding.)
Guo, Jiao (BGI-Shenzhen)
Pan, Shanshan (BGI-Shenzhen)
Fan, Guangyi (BGI-Shenzhen)
Zhang, Wei (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center)
Zhang, Ruitao (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding)
Yu, Jie (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine)
Zhang, Xinhao (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine)
Yin, Qi (BGI-Shenzhen)
Ji, Chuanliang (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine)
Jin, Yuanchun (BGI-Shenzhen)
Yue, Guidong (BGI-Shenzhen)
Liu, Mei (Nanjing Normal University. Jiangsu Key Laboratory for Molecular and Medical Biotechnology)
Xu, Jiake (The University of Western Australia . School of Biomedical Sciences)
Liu, Shimin (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Jordana i Vidal, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Noce, Antonia (Centre de Recerca en Agrigenòmica)
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica)
Wu, Dong-Dong (Chinese Academy of Sciences. Center for Excellence in Animal Evolution and Genetics)
Li, Shuaicheng (City University of Hong Kong. Department of Computer Science)
Zhou, Xiangshan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering)
Zhong, Jifeng (Jiangsu Academy of Agricultural Sciences. Institute of Animal Science)

Data:	2020
Resum:	Current knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. Population genomics analyses indicate that donkeys were domesticated in Africa and conclusively show reduced levels of Y chromosome variability and discordant paternal and maternal histories, possibly reflecting the consequences of reproductive management. We also investigate the genetic basis of coat color. While wild asses show diluted gray pigmentation (Dun phenotype), domestic donkeys display non-diluted black or chestnut coat colors (non-Dun) that were probably established during domestication. Here, we show that the non-Dun phenotype is caused by a 1 bp deletion downstream of the TBX3 gene, which decreases the expression of this gene and its inhibitory effect on pigment deposition.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Animals ; Breeding ; Chromosome Mapping ; Color ; Domestication ; Equidae ; Male ; Metagenomics ; Pigmentation ; Selection, Genetic ; Whole Genome Sequencing ; Y Chromosome
Publicat a:	Nature communications, Vol. 11 (December 2020) , art. 6014, ISSN 2041-1723

DOI: 10.1038/s41467-020-19813-7
PMID: 33293529

15 p, 4.1 MB

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