| Fecha: |
2021 |
| Resumen: |
The cerebrospinal fluid (CSF) biomarkers amyloid-β 1-42 (Aβ), total and phosphorylated tau (t-tau, p-tau) are increasingly used to assist in the clinical diagnosis of Alzheimer's disease (AD). However, CSF biomarker levels can be affected by confounding factors. To investigate the association of white matter hyperintensities (WMHs) present in the brain with AD CSF biomarker levels. We included CSF biomarker and magnetic resonance imaging (MRI) data of 172 subjects (52 controls, 72 mild cognitive impairment (MCI), and 48 AD patients) from 9 European Memory Clinics. A computer aided detection system for standardized automated segmentation of WMHs was used on MRI scans to determine WMH volumes. Association of WMH volume with AD CSF biomarkers was determined using linear regression analysis. A small, negative association of CSF Aβ, but not p -tau and t -tau, levels with WMH volume was observed in the AD (r 2 = 0. 084, p = 0. 046), but not the MCI and control groups, which was slightly increased when including the distance of WMHs to the ventricles in the analysis (r 2 = 0. 105, p = 0. 025). Three global patterns of WMH distribution, either with 1) a low, 2) a peak close to the ventricles, or 3) a high, broadly-distributed WMH volume could be observed in brains of subjects in each diagnostic group. Despite an association of WMH volume with CSF Aβ levels in AD patients, the occurrence of WMHs is not accompanied by excess release of cellular proteins in the CSF, suggesting that WMHs are no major confounder for AD CSF biomarker assessment. |
| Ayudas: |
Instituto de Salud Carlos III PI11-3035
Instituto de Salud Carlos III PI11-02425
Instituto de Salud Carlos III PI14-01126
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| Nota: |
Altres ajuts: Additionally, this work was funded by the CIBERNED program (Program 1, Alzheimer Disease), FondoEuropeo de Desarrollo Regional (FEDER), Unión Europea, "Una manera de hacer Europa" and a "Marató TV3" grant (grant number: 201412.10). |
| Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Lengua: |
Anglès |
| Documento: |
Article ; recerca ; Versió publicada |
| Materia: |
Alzheimer's disease ;
Amyloid ;
Biomarkers ;
Cerebrospinal fluid ;
Magnetic resonance imaging ;
Tau proteins ;
White matter hyperintensities ;
White matter lesions |
| Publicado en: |
Journal of Alzheimer's disease, Vol. 79 (january 2021) , p. 163-175, ISSN 1875-8908 |
visitante ::
identificación
(Institut d'Investigació Biomèdica Sant Pau)
