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Pàgina inicial > Articles > Articles publicats > A genome-wide association analysis for body, udder, and leg conformation traits recorded in Murciano-Granadina goats |
Data: | 2020 |
Resum: | Morphological traits are of great importance to dairy goat production given their effect on phenotypes of economic interest. However, their underlying genomic architecture has not yet been extensively characterized. Herein, we aimed to identify genomic regions associated with body, udder, and leg conformation traits recorded in 825 Murciano-Granadina goats. We genotyped this resource population using the GoatSNP50 BeadChip (Illumina Inc. , San Diego, CA) and performed genome-wide association analyses using the GEMMA software. We found 2 genome-wide significant associations between markers rs268273468 [Capra hircus (CHI) 16:69617700] and rs268249346 (CHI 28:18321523) and medial suspensory ligament. In contrast, we did not detect any genome-wide significant associations for body and leg traits. Moreover, we found 12, 19, and 7 chromosome-wide significant associations for udder, body, and leg traits, respectively. Comparison of our data with previous studies revealed a low level of positional concordance between regions associated with morphological traits. In addition to technical factors, this lack of concordance could be due to a substantial level of genetic heterogeneity among breeds or to the strong polygenic background of morphological traits, which makes it difficult to detect genetic factors that have small phenotypic effects. |
Ajuts: | Ministerio de Ciencia e Innovación AGL2016-76108-R Ministerio de Economía y Competitividad SEV-2015-0533 Ministerio de Economía y Competitividad BES-2017-079709 Ministerio de Educación, Cultura y Deporte FPU15/01733 |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió acceptada per publicar |
Matèria: | Genome-wide association study (GWAS) ; Goat ; Murciano-Granadina ; Morphological trait |
Publicat a: | Journal of dairy science, Vol. 103, Issue 12 (December 2020) , p. 11605-11617, ISSN 1525-3198 |
Postprint 55 p, 2.5 MB |
Supplementary table 2 xlsx file 16.0 KB |