Immune cell subtypes and cytokines in lung tumor microenvironment : Influence of COPD
Tang, Jun ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Hospital del Mar d'Investigacions Mèdiques)
Ramis-Cabrer, Daniel ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Hospital del Mar d'Investigacions Mèdiques)
Curull Serrano, Víctor (Institut Hospital del Mar d'Investigacions Mèdiques)
Wang, Xuejie ![Identificador ORCID](/img/uab/orcid.ico)
(Institut Hospital del Mar d'Investigacions Mèdiques)
Qin, Liyun (Institut Hospital del Mar d'Investigacions Mèdiques)
Mateu-Jiménez, Mercè (Institut Hospital del Mar d'Investigacions Mèdiques)
Duran-Jordà, Xavier
(Institut Hospital del Mar d'Investigacions Mèdiques)
Pijuan, Lara
(Institut Hospital del Mar d'Investigacions Mèdiques)
Rodríguez-Fuster, Alberto
(Institut Hospital del Mar d'Investigacions Mèdiques)
Aguiló Espases, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)
Barreiro, Esther
(Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona
Data: |
2020 |
Resum: |
Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by T regulatory (Treg), natural killer (NK), and plasma cells, as well as interleukin (IL)-10 and interferon-gamma, may differ within tumors of LC patients with/without COPD. Methods: Treg (anti-CD3 and anti-forkhead boxP3 antibodies), NK (anti-NCR1 antibody), IgG (anti-CD138-IgG antibody), IgA (anti-CD138-IgA antibody) using immunohistochemistry, and both IL-10 and interferon-gamma (ELISA) were quantified in tumor and non-tumor specimens (thoracotomy for lung tumor resection) from 33 LC-COPD patients and 20 LC-only patients. Results: Immune profile in tumor versus non-tumor specimens: Treg cell counts significantly increased in tumors of both LC and LC-COPD patients, while in tumors of the latter group, IgG-secreting plasma cells significantly decreased and IL-10 increased. No significant differences were seen in levels of NK cells, IgA-secreting cells, IgA/IgG, or interferon-gamma. Immune profile in tumors of LC-COPD versus LC: No significant differences were observed in tumors between LC-COPD and LC patients for any study marker. Conclusions: Immune cell subtypes and cytokines are differentially expressed in lung tumors, and the presence of COPD elicited a decline in IgG-secreting plasma cell levels but not in other cell types. |
Ajuts: |
Instituto de Salud Carlos III FIS18-00075
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Drets: |
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Llengua: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Publicat a: |
Cancers, Vol. 12 Núm. 5 (may 2020) , p. 1217, ISSN 2072-6694 |
DOI: 10.3390/cancers12051217
PMID: 32414037
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